NR3C1

  • Official Full Name

    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

  • Overview

    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

  • Synonyms

    NR3C1;nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor);GR;GCR;GRL;GCCR;glucocorticoid receptor;glucocorticoid nuclear receptor variant 1

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • Sf21 Cells
  • Insect Cells
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • SUMO
  • GST
  • Non
  • Flag
  • Trx
Cat.# Product name Source (Host) Species Tag Protein Length Price
NR3C1-106H Recombinant Human NR3C1 protein, His-SUMO-tagged E.coli Human His&SUMO Leu532~Glu730
NR3C1-8490H Active Recombinant Human NR3C1, His-tagged Sf21 Cells Human His
NR3C1-1044H Recombinant Human NR3C1 protein, His-tagged Insect Cells Human His
NR3C1-104H Recombinant Human Glucocorticoid receptor LBD/Hsp90 complex, GST-tagged Sf9 Cells Human GST
NR3C1-2867Z Recombinant Zebrafish NR3C1 Mammalian Cells Zebrafish His
NR3C1-28739TH Recombinant Human NR3C1, His-tagged Human His Full L. 1-777 a.a.
NR3C1-3295C Recombinant Chicken NR3C1 Mammalian Cells Chicken His
Nr3c1-7164R Recombinant Rat Nr3c1 protein, His-tagged E.coli Rat His Ser106~Thr211
Nr3c1-7165R Recombinant Rat Nr3c1 protein, His & GST-tagged E.coli Rat GST&His Ala564~Phe733
Nr3c1-7651M Recombinant Mouse Nr3c1 protein, His-tagged E.coli Mouse His Ala622~Phe755
NR3C1-1218HCL Recombinant Human NR3C1 cell lysate Human Non
NR3C1-0611H Recombinant Human NR3C1 Protein (Gln529-Lys779), N-His-tagged Insect Cells Human His Gln529-Lys779
NR3C1-0612H Recombinant Human NR3C1 Protein (Met1-Lys777), C-His-tagged Insect Cells Human His Met1-Lys777
NR3C1-1104HFL Recombinant Human NR3C1 protein, His&Flag-tagged HEK293 Human Flag&His 1-777 aa
NR3C1-1853H Recombinant Human NR3C1 Protein, His&GST-tagged E.coli Human GST&His Tyr598-Glu755
Nr3c1-1854M Recombinant Mouse Nr3c1 Protein, His-tagged E.coli Mouse His Lys254-Gly393
NR3C1-2506H Recombinant Human NR3C1 Protein, His-tagged E.coli Human His Leu528-Lys777
NR3C1-2507H Recombinant Human NR3C1 Protein, His-tagged E.coli Human His Leu528-Ile742
NR3C1-2750H Recombinant Human NR3C1 Protein, His-tagged E.coli Human His Val521-Lys777
NR3C1-3290H Recombinant Human NR3C1 protein, His-GST-tagged E.coli Human GST&His 521-777aa
NR3C1-3291H Recombinant Human NR3C1 protein, His-Trx-tagged E.coli Human His&Trx 521-777aa
NR3C1-4216H Recombinant Human NR3C1 Protein (Val271-Lys777), N-His tagged E.coli Human His Val271-Lys777
NR3C1-4217H Recombinant Human NR3C1 Protein (Gln529-Lys779), N-His tagged Mammalian Cells Human His Gln529-Lys779
NR3C1-4633H Recombinant Human NR3C1 protein, His-SUMO-tagged E.coli Human His&SUMO 521-777a.a.
NR3C1-6090H Recombinant Human NR3C1 Protein, GST-tagged Wheat Germ Human GST
NR3C1-6743HF Recombinant Full Length Human NR3C1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 777 amino acids

    Involved Pathway

    NR3C1 involved in several pathways and played different roles in them. We selected most pathways NR3C1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction MC2R,GRIK1,GRIN1B,P2RX1,TAAR14J,P2RX4A,ADRB2A,TAAR14B,GRIA3B,RXFP3

    Protein Function

    NR3C1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,glucocorticoid receptor activity,glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C1 itself. We selected most functions NR3C1 had, and list some proteins which have the same functions with NR3C1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PLAU,RAD21,SLC39A13,RPUSD3,P4HA2,C9orf86,PML,PRR3,CDK5,GADD45B
    RNA polymerase II core promoter proximal region sequence-specific DNA binding TBX3,MYOD1,FOXI1,MITF,GMEB2,POU3F2,MYOG,ZNF331,ZNF713,ZNF664
    transcription factor activity, sequence-specific DNA binding MZF1,MAP3K7,NFIL3-4,HOXB8B,FLI1B,NFIL3-6,FOXB1B,MNX2B,CBFB,SMAD1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PITX1,JUN,SOX4,NKX2,NFATC3,TRP53,ATF2,PBX1,E2F4,TLX1
    steroid binding ESR2B,PAQR5B,SERPINA6,ESRRA,Ar,PGRMC2,PAQR5A,HSD17B10,CYP3A4,PGR
    zinc ion binding MUL1A,MYNN,NR5A1,CHMP1A,SEC23B,GATA2,SEC24A,ACE,BHMT,MEP1A.1
    steroid hormone binding ATP1A1,GPR30,ESR2A,ESR2B,ATP1A2,ATP1A3

    Interacting Protein

    NR3C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C1.

    HSP90AA1;dexamethasone;HSPA1A;AKT1

    Resources

    Research Area

    Transcription Regulators in VSMC

    References

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