NR2E3
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Official Full Name
nuclear receptor subfamily 2, group E, member 3 -
Overview
This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
NR2E3;nuclear receptor subfamily 2, group E, member 3;photoreceptor-specific nuclear receptor;PNR;rd7;RP37;ESCS;MGC49976;NR2 E3;Nuclear receptor subfamily 2 group E member 3;Photoreceptor specific nuclear receptor;Rd 7;Retina specific nuclear receptor;Retinal degeneration 7;RNR;retina-specific nuclear receptor;photoreceptor cell-specific nuclear receptor variant 1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- Non
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NR2E3-1358H | Recombinant Human NR2E3, His-tagged | E.coli | Human | His | C-term-322aa | |
| NR2E3-1090H | Recombinant Human NR2E3 protein, His & GST-tagged | E.coli | Human | His&GST | Met1~Asn410 |
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| NR2E3-1756Z | Recombinant Zebrafish NR2E3 | Mammalian Cells | Zebrafish | His |
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| NR2E3-6163C | Recombinant Chicken NR2E3 | Mammalian Cells | Chicken | His |
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| NR2E3-3711HCL | Recombinant Human NR2E3 293 Cell Lysate | HEK293 | Human | Non |
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| NR2E3-1583H | Recombinant Human NR2E3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Nr2e3-4490M | Recombinant Mouse Nr2e3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NR2E3-6083H | Recombinant Human NR2E3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NR2E3-6739HF | Recombinant Full Length Human NR2E3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 322 amino acids |
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Involved Pathway
NR2E3 involved in several pathways and played different roles in them. We selected most pathways NR2E3 participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | TRMT112,HNRPL,NRBF2B,ZNF557,THG1L,ZNF791,ZFP2,EEF1D,ZNF785,ZNF383 |
| Nuclear Receptor transcription pathway | NR1D2A,NR2C2,NR5A1B,NR2F6B,NR2F6,NR1I2,NR6A1A,ESRRGA,NR5A1A,NRBF2B |
| Generic Transcription Pathway | ZNF460,ZNF256,ZNF558,NRBP1,ZNF331,PSTPIP2,MED23,ZNF706,PPARAA,ZNF350 |
Protein Function
NR2E3 has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR2E3 itself. We selected most functions NR2E3 had, and list some proteins which have the same functions with NR2E3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid hormone receptor activity | NR2F6,PGR,NR1I2,NR5A1,OLFR78,RORC,PPARAA,NR1H5,NR2E1,NR2C1 |
| zinc ion binding | PPARA,RFPL2,RPS29,USP44,NEIL1,NR3C1,TRIM52,RNF40,RNF26,ACE2 |
| protein binding | STX12,NFKBIE,DHX36,THAP3,ZNF394,RIPK1,FHL5,HNRNPA2B1,RACGAP1,TUBA3D |
| sequence-specific DNA binding | RXRAA,HOXA9,ZNF148,IRX7,GATA1,USF2,MAFK,HOXD13A,HOXA9B,NKX3.3 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | PGR,NR5A1A,NR2F1,NR4A1,NR1H3,NR2F2,HNF4A,NR4A2,NR2F6,PPARDB |
Interacting Protein
NR2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR2E3.
CDK9;DHX30;HDAC3;NCOR1;RBL1;RBBP4;TBL3;HDAC1
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References
- Bracci, PM; Zhou, M; et al. Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study. CANCER 118:5384-5394(2012).
- Kautzmann, MAI; Kim, DS; et al. Combinatorial Regulation of Photoreceptor Differentiation Factor, Neural Retina Leucine Zipper Gene Nrl, Revealed by in Vivo Promoter Analysis. JOURNAL OF BIOLOGICAL CHEMISTRY 286:28247-28255(2011).
