NOX4

  • Official Full Name

    NADPH oxidase 4

  • Overview

    This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

  • Synonyms

    NOX4;NADPH oxidase 4;KOX;KOX 1;kidney oxidase-1;renal NAD(P)H-oxidase;kidney superoxide-producing NADPH oxidase;KOX-1;RENOX

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Sumatran orangutan
  • Mouse
  • Pongo Abelii
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • In vitro E. coli expression system
  • Yeast
  • In Vitro Cell Free System
  • In vitro E.coli expression system
  • HEK293
  • E.coli expression system
  • GST
  • His
  • Non
  • His&B2M
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NOX4-1336H Recombinant Human NOX4, GST-tagged E.coli Human GST 224-578aa
NOX4-1977H Recombinant Human NOX4 protein, His-tagged E.coli Human His Asp220~Asp392
NOX4-22H Recombinant Human NOX4 Protein Wheat Germ Human Non
NOX4-29711TH Recombinant Human NOX4 Wheat Germ Human Non 100 amino acids
NOX4-3740C Recombinant Chicken NOX4 Mammalian Cell Chicken His
NOX4-4032R Recombinant Rat NOX4 Protein Mammalian Cell Rat His
NOX4-1328S Recombinant Sumatran orangutan NOX4 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Sumatran orangutan His Full L. 1-578aa
NOX4-1475R Recombinant Rat NOX4 Protein (210-424 aa), His-tagged Yeast Rat His 210-424 aa
NOX4-1539HF Recombinant Full Length Human NOX4 Protein In Vitro Cell Free System Human Full L. 578 amino acids
Nox4-1840M Recombinant Mouse Nox4 Protein, His-tagged E.coli Mouse His Gly210-Ser578
NOX4-2200R Recombinant Rat NOX4 Protein (210-424 aa), His-B2M-tagged E.coli Rat His&B2M 210-424 aa
NOX4-2499H Recombinant Human NOX4 Protein, His-tagged E.coli Human His Leu446-Ser578
NOX4-2783H Recombinant Human NOX4 Protein (Gly210-Glu424), His tagged E.coli Human His Gly210-Glu424
NOX4-2948H Recombinant Human NOX4 Transmembrane protein, His-tagged In vitro E.coli expression system Human His 210-424aa
NOX4-298H Recombinant Human NOX4 protein, His-tagged(VLPs) HEK293 Human His 1-578aa
NOX4-3282H Recombinant Human NOX4 protein, His-tagged E.coli Human His 210-424aa
NOX4-3691R Recombinant Rat NOX4 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NOX4-3691R-B Recombinant Rat NOX4 Protein Pre-coupled Magnetic Beads HEK293 Rat
NOX4-6008H Recombinant Human NOX4 Protein, GST-tagged Wheat Germ Human GST
RFL16211RF Recombinant Full Length Rat Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (210-424)
RFL28341HF Recombinant Full Length Human Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-578aa)
RFL35916PF Recombinant Full Length Pongo Abelii Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system Pongo Abelii His Full L. Full Length (1-578aa)

    Involved Pathway

    NOX4 involved in several pathways and played different roles in them. We selected most pathways NOX4 participated on our site, such as Oxidative Stress,Signaling events mediated by PTP1B,Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spinal Cord Injury RTN4R,PTPRZ1,RTN4,KLK8,GDNF,GAP43,TNFSF13B,LGALS3,AIF1,OMG
    Signaling events mediated by PTP1B YBX1,CSN2,DOK1
    Oxidative Stress NQO1,NFIX,JUNBA,TXNRD2,TXN2

    Protein Function

    NOX4 has several biochemical functions, for example, NAD(P)H oxidase activity,electron carrier activity,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX4 itself. We selected most functions NOX4 had, and list some proteins which have the same functions with NOX4. You can find most of the proteins on our site.

    Function Related Protein
    NAD(P)H oxidase activity KMO,DUOX2,AIFM1,CYB5R4,DERL3
    flavin adenine dinucleotide binding NOS1,ETFA,ACAD11,FMO5,NOS2,DHCR24,FMO1,DMGDH,MTO1,ACAD9
    electron carrier activity CYP19A1,DERL3,NDUFA12,PHGDH,GCDHB,GLRX2,ACADL,AOX4,QDPR,FDX1B
    superoxide-generating NADPH oxidase activity SH3PXD2AA,CYBB,NOX1,NOX3,NCF1,NOX5,PAX2
    oxygen sensor activity HIF1AN,EGLN2
    nucleotide binding UBE2NB,NTRK2B,ZNF143B,ZCRB1,HNRNPL,RAB1BB,SRSF1A,SRSF5B,HNRNPA0L,DDX51
    modified amino acid binding MTHFR,CPS1,DPEP1,MUT,CBS
    heme binding CYB5A,EPX,HMOX1,CYP2C54,CYP1D1,CYP2A12,CYP7A1A,CYP17A1,CYP2Y3,CYP4V8

    Interacting Protein

    NOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX4.

    Resources

    Research Area

    Inflammatory Mediators
    ROS and Stress Resistance

    References

    • Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).
    • Nayernia, Z; Jaquet, V; et al. New Insights on NOX Enzymes in the Central Nervous System. ANTIOXIDANTS & REDOX SIGNALING 20:2815-2837(2014).

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