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NODAL

  • Official Full Name

    nodal growth differentiation factor
  • Overview

    The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]
  • Synonyms

    NODAL;nodal growth differentiation factor;HTX5;nodal homolog

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • E. coli
  • In Vitro Cell Free System
  • His
  • Non
  • Flag
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NODAL-2913H Recombinant Human NODAL protein, His-tagged E.coli Human His 40-338 aa
NODAL-28M Recombinant Mouse Nodal E.coli Mouse Non
NODAL-30448TH Recombinant Human NODAL Wheat Germ Human Non 275-346a.a.
NODAL-30H Recombinant Human Nodal E.coli Human Non 238-347a.a.
NODAL-528H Recombinant Human NODAL Mammalian Cell Human His 245-354a.a.
NODAL-3771HCL Recombinant Human NODAL 293 Cell Lysate HEK293 Human Flag 1-347a.a.
NODAL-0527M Recombinant Mouse NODAL protein, GST-tagged E.coli Mouse GST 245-354 a.a.
NODAL-0528H Recombinant Human NODAL protein, GST-tagged E.coli Human GST 238-347 a.a.
Nodal-1833M Recombinant Mouse Nodal Protein, His-tagged E.coli Mouse His His245-Leu354
NODAL-235H Active Recombinant Human NODAL Protein (His238-Leu347), C-His tagged, Animal-free, Carrier-free E.coli Human His His238-Leu347
NODAL-2494H Recombinant Human NODAL Protein, His-tagged E.coli Human His Ala27-Leu347
NODAL-29M Recombinant Mouse NODAL Protein, His-tagged E.coli Mouse His His245~Leu354
NODAL-31H Recombinant Human NODAL Protein, His-tagged E. coli Human His His238-Leu347aa
NODAL-3648H Recombinant Human NODAL Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
NODAL-3648H-B Recombinant Human NODAL Protein Pre-coupled Magnetic Beads HEK293 Human
NODAL-5964H Recombinant Human NODAL Protein, GST-tagged Wheat Germ Human GST 1-326a.a.
NODAL-6680HF Recombinant Full Length Human NODAL Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 326 amino acids

    Involved Pathway

    NODAL involved in several pathways and played different roles in them. We selected most pathways NODAL participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with NODAL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway TFDP1A,BMP7A,BMPR2,ACVR1C,SMAD7,FSTA,SMAD6,NOG2,SMAD3A,RHOA
    Signaling pathways regulating pluripotency of stem cells INHBC,FGFR1,DLX5,SMAD5,TCF3,WNT2,ONECUT1,WNT4,PCGF1,WNT3

    Protein Function

    NODAL has several biochemical functions, for example, cytokine activity,growth factor activity,morphogen activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NODAL itself. We selected most functions NODAL had, and list some proteins which have the same functions with NODAL. You can find most of the proteins on our site.

    Function Related Protein
    type I activin receptor binding SMAD6,NDR2,SPAW,NDR1
    cytokine activity GREM2,RNF207B,IL18,Cxcl15,IFNK,TNFSF13B,TSLP,IL15,LFT2,IL3
    transforming growth factor beta receptor binding GDF3,GDF1,INHBE,SMURF2,TGFB1A,BMP10,NDR2,TGFB2,TGFBR3,NDR1
    growth factor activity IL10,PROK1,KLK1B3,VEGFAA,DKK1,FGF10,HDGF,AMH,INHBE,FGF6B
    morphogen activity DAND5,CER1,NBL1,Shh,GREM1
    receptor agonist activity WNT1,SFRP2,WNT10B,WNT2,WNT5A,CXCL13,WNT7A,GAS6,WNT8A,VEGFA

    Interacting Protein

    NODAL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NODAL here. Most of them are supplied by our site. Hope this information will be useful for your research of NODAL.

    Resources

    References

    • Cardona, C; Sanchez-Mejias, E; et al. Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes. GLIA 63:365-382(2015).
    • Rutgen, BC; Gerner, W; et al. Exploratory assessment of CD4(+) T lymphocytes in brown hares (Lepus europeus) using a cross-reactive anti-rabbit CD4 antibody. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 161:108-115(2014).