NODAL
-
Official Full Name
nodal growth differentiation factor -
Overview
The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008] -
Synonyms
NODAL;nodal growth differentiation factor;HTX5;nodal homolog
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- E. coli
- In Vitro Cell Free System
- His
- Non
- Flag
- GST
- His&Fc&Avi
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
NODAL-2913H | Recombinant Human NODAL protein, His-tagged | E.coli | Human | His | 40-338 aa | |
NODAL-28M | Recombinant Mouse Nodal | E.coli | Mouse | Non | ||
NODAL-30448TH | Recombinant Human NODAL | Wheat Germ | Human | Non | 275-346a.a. | |
NODAL-30H | Recombinant Human Nodal | E.coli | Human | Non | 238-347a.a. | |
NODAL-528H | Recombinant Human NODAL | Mammalian Cell | Human | His | 245-354a.a. | |
NODAL-3771HCL | Recombinant Human NODAL 293 Cell Lysate | HEK293 | Human | Flag | 1-347a.a. | |
NODAL-0527M | Recombinant Mouse NODAL protein, GST-tagged | E.coli | Mouse | GST | 245-354 a.a. | |
NODAL-0528H | Recombinant Human NODAL protein, GST-tagged | E.coli | Human | GST | 238-347 a.a. | |
Nodal-1833M | Recombinant Mouse Nodal Protein, His-tagged | E.coli | Mouse | His | His245-Leu354 | |
NODAL-235H | Active Recombinant Human NODAL Protein (His238-Leu347), C-His tagged, Animal-free, Carrier-free | E.coli | Human | His | His238-Leu347 | |
NODAL-2494H | Recombinant Human NODAL Protein, His-tagged | E.coli | Human | His | Ala27-Leu347 | |
NODAL-29M | Recombinant Mouse NODAL Protein, His-tagged | E.coli | Mouse | His | His245~Leu354 | |
NODAL-31H | Recombinant Human NODAL Protein, His-tagged | E. coli | Human | His | His238-Leu347aa | |
NODAL-3648H | Recombinant Human NODAL Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi | ||
NODAL-3648H-B | Recombinant Human NODAL Protein Pre-coupled Magnetic Beads | HEK293 | Human | |||
NODAL-5964H | Recombinant Human NODAL Protein, GST-tagged | Wheat Germ | Human | GST | 1-326a.a. | |
NODAL-6680HF | Recombinant Full Length Human NODAL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 326 amino acids |
Involved Pathway
NODAL involved in several pathways and played different roles in them. We selected most pathways NODAL participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with NODAL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
TGF-beta signaling pathway | TFDP1A,BMP7A,BMPR2,ACVR1C,SMAD7,FSTA,SMAD6,NOG2,SMAD3A,RHOA |
Signaling pathways regulating pluripotency of stem cells | INHBC,FGFR1,DLX5,SMAD5,TCF3,WNT2,ONECUT1,WNT4,PCGF1,WNT3 |
Protein Function
NODAL has several biochemical functions, for example, cytokine activity,growth factor activity,morphogen activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NODAL itself. We selected most functions NODAL had, and list some proteins which have the same functions with NODAL. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
type I activin receptor binding | SMAD6,NDR2,SPAW,NDR1 |
cytokine activity | GREM2,RNF207B,IL18,Cxcl15,IFNK,TNFSF13B,TSLP,IL15,LFT2,IL3 |
transforming growth factor beta receptor binding | GDF3,GDF1,INHBE,SMURF2,TGFB1A,BMP10,NDR2,TGFB2,TGFBR3,NDR1 |
growth factor activity | IL10,PROK1,KLK1B3,VEGFAA,DKK1,FGF10,HDGF,AMH,INHBE,FGF6B |
morphogen activity | DAND5,CER1,NBL1,Shh,GREM1 |
receptor agonist activity | WNT1,SFRP2,WNT10B,WNT2,WNT5A,CXCL13,WNT7A,GAS6,WNT8A,VEGFA |
Interacting Protein
NODAL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NODAL here. Most of them are supplied by our site. Hope this information will be useful for your research of NODAL.
Resources
Research Area
Early Mesodermal Lineage MarkersOther Cytokines & Receptors
Ectodermal Lineage Markers
Mesodermal Lineage Markers
Related Services
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References
- Cardona, C; Sanchez-Mejias, E; et al. Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes. GLIA 63:365-382(2015).
- Rutgen, BC; Gerner, W; et al. Exploratory assessment of CD4(+) T lymphocytes in brown hares (Lepus europeus) using a cross-reactive anti-rabbit CD4 antibody. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 161:108-115(2014).