NMUR1
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Official Full Name
neuromedin U receptor 1 -
Synonyms
NMUR1;neuromedin U receptor 1;G protein coupled receptor 66 , GPR66;neuromedin-U receptor 1;FM 3;GPC R;NMU1R;FM-3;G protein-coupled receptor 66;GPR66;Growth hormone secretagogue receptor family Member 3;NMU-R1;G-protein coupled receptor 66;G-protein coupled receptor FM-3;FM3;GPC-R;(FM-3)
Recombinant Proteins
- Mouse
- Rat
- Human
- Mus musculus
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- His&Fc&Avi
- Non
- GST
Involved Pathway
NMUR1 involved in several pathways and played different roles in them. We selected most pathways NMUR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMUR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (i) signalling events | LPAR1,TAS2R13,CNR1,RGS10,CNR2,NMS,ADORA1,OXGR1A.1,PNOC,OXGR1 |
| G alpha (q) signalling events | TAC2,FFAR3,QRFPR,AGT,UTS2,ADRA1D,LTB4R,OPN4.1,CASR,TAC1 |
| Class A/1 (Rhodopsin-like receptors) | POMCB,RGR,NPFF,GPR37L1,SST,ADORA3,EDNRAB,AGTR2,CCK,S1PR5B |
| Neuroactive ligand-receptor interaction | PPYR1,P2RY14,HTR1B,HRH2,KISS1R,TAAR11,NPY4R,GABRA4,CCKAR,GABRB1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | GPR132B,QRFP,FPR-RS6,ANXA1B,HCRT,LPAR1,DGKA,FPR-RS3,EDN2,NPFF |
| GPCR ligand binding | OPN1LW1,OXGR1,ADORA2B,CALCA,FPR-RS6,RGS1,DRD3,ADM,CCL19A.2,GPR132 |
| GPCRs, Class A Rhodopsin-like | GPR68,NPFFR2,ADORA1,SSTR3,APLNR,CX3CR1,LTB4R,OPN1MW2,FFAR3,GPR6 |
| GPCR downstream signaling | GPR65,GPBAR1,OXGR1A.3,OPN4A,PTH2,RHOGA,ARHGEF3,TIAM2,INSL3,GPRC6A |
Protein Function
NMUR1 has several biochemical functions, for example, G-protein coupled receptor activity,neuromedin U receptor activity,neuropeptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMUR1 itself. We selected most functions NMUR1 had, and list some proteins which have the same functions with NMUR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | C3AR1,GPR6,OLFR688,TAAR13D,TAAR12F,VMN1R40,GNRHR4,GPR151,OR2K2,OLFR78 |
| neuropeptide receptor activity | NPFFR1L3,NPSR1,HCRTR1,SORCS2,NPFFR2.1,NPFFR1L2,NPFFR1L1,PRLHR,SORCS3,GPR139 |
| neuromedin U receptor activity | NMUR2 |
Interacting Protein
NMUR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMUR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMUR1.
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References
- Zhang, YM; Jiang, DS; et al. Neuromedin U Type 1 Receptor Stimulation of A-type K+ Current Requires the beta gamma Subunits of G(o) Protein, Protein Kinase A, and Extracellular Signal-regulated Kinase 1/2 (ERK1/2) in Sensory Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18562-18572(2012).
- Chen, RX; Liu, F; et al. Neuromedin S Increases L-type Ca2+ Channel Currents Through G(i)alpha-protein and Phospholipase C-dependent Novel Protein Kinase C Delta Pathway in Adult Rat Ventricular Myocytes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 30:618-630(2012).
- Zhang, YA; Jiang, DS; et al. Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons. CELLULAR SIGNALLING 22:1660-1668(2010).
