NLK

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    nemo-like kinase
  • Overview

    Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
  • Synonyms

    NLK;nemo-like kinase;serine/threonine-protein kinase NLK

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
NLK-1306H Recombinant Human NLK, His-tagged E.coli Human His 159-515aa
NLK-1066H Active Recombinant Human NLK, GST-tagged Sf9 Cells Human GST Full Length
NLK-1066 Recombinant Human NLK protein, GST-tagged Insect Cells Human GST Full Length
NLK-10711M Recombinant Mouse NLK Protein Mammalian Cells Mouse His
NLK-28098TH Recombinant Human NLK Sf9 Cells Human Non 527 amino acids
NLK-3998R Recombinant Rat NLK Protein Mammalian Cells Rat His
NLK-7318H Active Recombinant Human NLK protein, His&GST-tagged Insect Cells Human GST&His 121-527 a.a.
NLK-409HCL Recombinant Human NLK cell lysate Insect Cells Human Non
NLK-1010H Recombinant Human NLK Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NLK-3657R Recombinant Rat NLK Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
NLK-3657R-B Recombinant Rat NLK Protein Pre-coupled Magnetic Beads HEK293 Rat
Nlk-4432M Recombinant Mouse Nlk Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
NLK-5651H Recombinant Human NLK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NLK-5916H Recombinant Human NLK Protein, GST-tagged Wheat Germ Human GST
NLK-6091M Recombinant Mouse NLK Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
NLK-6091M-B Recombinant Mouse NLK Protein Pre-coupled Magnetic Beads HEK293 Mouse
NLK-6716HF Recombinant Full Length Human NLK Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 515 amino acids
NLK-7844H Recombinant Human NLK protein, His&Myc-tagged E.coli Human His&Myc 1-527a.a.

Involved Pathway

NLK involved in several pathways and played different roles in them. We selected most pathways NLK participated on our site, such as MAPK signaling pathway,FoxO signaling pathway,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathway PLK4,PRKAG3,MAPK8A,MAP2K2A,CCND1,NRAS,HOMER1B,SGK3,PRKAA1,BRAF
MAPK signaling pathway MOS,FGF6A,MAPK8A,CASP3A,NRAS,ARRB2,FGF14,RAF1B,FGF13A,CACNG2A
Adherens junction ACTN3,WASF3,TJP1,FYNB,VCL,PARD3,ACTN2,TGFBR2,VCLA,TCF7L2
Wnt signaling pathway CAMK2D1,CAMK2G1,PRICKLE1,WNT11,RHOAC,PPP3R2,DAAM1,CXXC4,NKD2B,MAP3K7

Protein Function

NLK has several biochemical functions, for example, ATP binding,MAP kinase activity,SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLK itself. We selected most functions NLK had, and list some proteins which have the same functions with NLK. You can find most of the proteins on our site.

Function Related Protein
transcription factor binding SUFU,DIP2C,PPP1R13L,RBPJ,HMGA2,NFKB1,EP300,TBP,TFDP1,GTF2A2
MAP kinase activity NLK2,MAPK14,MAPK4,MAPK12,MAPK12A,MAPK6,NLK1,MAPK8B,MAPK11,MAPK14A
magnesium ion binding PGM1,PTEN,TSSK4,RPS6KA4,ATP8B5,ICK,NLRC4,IDH3A,TESC,IDH3B
protein kinase activity PRKCHB,RASSF2,PRKDC,MAP3K4,LTK,MAP3K1,RPS6KB1B,PKDCC,NEK12,CDK5
SH2 domain binding CTR9,PTK2,NUP62,CRK,DAG1,LAT2,SRC,INPPL1,MS4A2,LILRB1
protein binding GPA33,HIST1H2AM,RAB6B,AKAP1,IRS4,ANKRD45,FAM72A,AP4M1,AIPL1,ZC3HAV1
ATP binding DDX54,SGK196,SMARCA5,PEX1,UBE2G1,GTF2F2,UBE2G1B,MCM4,CARS,NLRC4
protein serine/threonine kinase activity MAP2K5,STK24,VRK3,TTBK2,HIPK2,ROCK2,EIF2AK4,KSR2,MAPK13,STK40
ubiquitin protein ligase binding CASP10,HERC2,OTUB1,PRDX6,ZFP746,KCNQ3,DNM1L,LC3,CUL3B,TCEB2

Interacting Protein

NLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLK here. Most of them are supplied by our site. Hope this information will be useful for your research of NLK.

SMAD4;ZHX3;RCHY1;MAP3K7;N/A

NLK Related Signal Pathway

Resources

References

  • Rosenbaek, LL; Assentoft, M; et al. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. JOURNAL OF PHYSIOLOGY-LONDON 590:6121-6139(2012).
  • Gnanapavan, S; Carrol, C; et al. Paraneoplastic opsoclonus-myoclonus associated with metastatic melanoma and anti-neuroleukin (NLK) antibodies. JOURNAL OF NEUROIMMUNOLOGY 197:174-174(2008).

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