NFYC
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Official Full Name
nuclear transcription factor Y, gamma -
Overview
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NFYC;nuclear transcription factor Y, gamma;nuclear transcription factor Y subunit gamma;CBF C;NF YC;transactivator HSM-1;transactivator HSM-1/2;CCAAT binding factor subunit C;transcription factor NF-Y, C subunit;CAAT box DNA-binding protein subun
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His&GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFYC-308H | Recombinant Human NFYC Protein, His/GST-tagged | E.coli | Human | His&GST | Met1~Val263 | |
| NFYC-10040Z | Recombinant Zebrafish NFYC | Mammalian Cells | Zebrafish | His |
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| NFYC-29920TH | Recombinant Human NFYC | Wheat Germ | Human | Non | 100 amino acids |
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| NFYC-3979R | Recombinant Rat NFYC Protein | Mammalian Cells | Rat | His |
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| NFYC-3838HCL | Recombinant Human NFYC 293 Cell Lysate | HEK293 | Human | Non |
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| NFYC-2446H | Recombinant Human NFYC Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| NFYC-3638R | Recombinant Rat NFYC Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NFYC-3638R-B | Recombinant Rat NFYC Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Nfyc-4403M | Recombinant Mouse Nfyc Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NFYC-4700H | Recombinant Human NFYC Protein (Met1-Val263), N-GST tagged | E.coli | Human | GST | Met1-Val263 |
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Involved Pathway
NFYC involved in several pathways and played different roles in them. We selected most pathways NFYC participated on our site, such as Antigen processing and presentation,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-F,TAPBP,H2-AA,KIR2DL3,TNF,KLRC2,HLA-DPB1,HSPA1A,CD8B,KLRC4 |
| Tuberculosis | MAPK9,CALML5,TGFB3,HLA-DQB1,HLA-DRB5,Casp3,PPP3R2,FCGR1,RFXAP,STAT1 |
Protein Function
NFYC has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYC itself. We selected most functions NFYC had, and list some proteins which have the same functions with NFYC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TBP,DLX2,HES1,FOXI1,SIN3A,MNX2B,ZSCAN4C,EHF,TBX5B,ZNF133 |
| contributes_to transcription regulatory region DNA binding | TAF1,NR1H3,HDAC5,TCF3,HAND1,NFYA,NFYB,TCF12,RXRA,ATF4 |
| protein heterodimerization activity | ATF1,CHRNB4,TYRP1,SFRP5,WHRN,HIST4H4,MEF2A,JDP2,HIST2H2AA4,ANO9A |
| transcription factor binding | HIF1A,CHCHD2,PPID,SP1,PPARGC1B,APBB1,PAX2,TMEM173,KAT2B,KEAP1 |
| protein binding | LIMS1,HORMAD1,WDR34,CRK,EIF1AY,TCL1A,RNF175,SGCA,PNMA5,TSC22D1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | E2F8,HINFP,NFATC2,RUNX2,POU4F2,SREBF1,ZGPAT,ELF3,NFE2L3,ZSCAN21 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | OTX1,BARHL2,GLIS2,MEIS3,TFAP4,CEBPA,NR4A3,MITFB,IRF1,KLF4 |
| transcription coactivator activity | ACTL6A,TAF6L,SOX17,TRIP4,DDX5,UBE2L3,ATXN7L3,NCOA1,RNF20,YAF2 |
| DNA binding | LHX2B,TFPT,H2AFJ,SETDB2,KDM5BA,ZNF280C,MAP3K7,ZFAT,SIX1,CLSPN |
Interacting Protein
NFYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYC here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYC.
NFYB;NFYA;SNX2;GAPDH;CSN2;SP1;ATF6;LMO4;DR1;DST;SREBF2;bipA;ARID2;KIAA2018
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References
- Tremblay, AM; Wilson, BJ; et al. Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. MOLECULAR ENDOCRINOLOGY 22:570-584(2008).
- Vila-Del Sol, V; Diaz-Munoz, MD; et al. Requirement of tumor necrosis factor at and nuclear factor-kappa B in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. JOURNAL OF LEUKOCYTE BIOLOGY 81:272-283(2007).
