NFYA
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Official Full Name
nuclear transcription factor Y, alpha -
Overview
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. -
Synonyms
NFYA;nuclear transcription factor Y, alpha;HAP2;CBF-A;CBF-B;NF-YA;FLJ11236;nuclear transcription factor Y subunit alpha;OTTHUMP00000016365;OTTHUMP00000016366;HAP2 CCAAT-binding protein;Transcription factor NF-Y, A subunit;CAAT box DNA-binding protein subunit A;nuclear transcription factor Y subunit A;CCAAT-binding transcription factor subunit B
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
NFYA involved in several pathways and played different roles in them. We selected most pathways NFYA participated on our site, such as Antigen processing and presentation,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HSPA4,CD8A,HLA-G,TAP1,CTSL1,HLA-DQA1,HSPA1A,HLA-DOA,KLRC1,H2-Q10 |
| Tuberculosis | CALM1,IFNA1,CARD9,CEBPG,ATP6AP1,MAPK8,ITGB2L,Il23a; Il12b,NFKB1,IFNA5 |
Protein Function
NFYA has several biochemical functions, for example, DNA binding,core promoter sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYA itself. We selected most functions NFYA had, and list some proteins which have the same functions with NFYA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GABRG2,TRAF7,NCLN,DDX47,ARVCF,TAPBP,ADRBK1,FGF19,CAPNS2,SSTR2 |
| DNA binding | LBX1B,HOXD4A,ZFP879,SALL1,HOXA13A,RAD51C,MLXIPL,ISL2,HMG20B,APEX1 |
| contributes_to transcription regulatory region DNA binding | RXRA,TCF12,TAF1,NFYC,HDAC4,TCF3,NR1H3,NFYB,HDAC5,HAND1 |
| transcription factor activity, sequence-specific DNA binding | LMX1B,HOXB3,ASCL1B,JUNBB,TFDP1B,ZNF157,E4F1,ZFP161,E2F5,EGR2A |
| core promoter sequence-specific DNA binding | CRY1,RORA,SOHLH2,ESR2,ZFP750,CHD2,NRF1,TOP1,TRP53,ZFP932 |
Interacting Protein
NFYA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYA here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYA.
NFYB;NFYC;APPBP2;SRSF1
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References
- Kim, YW; Jung, HJ; et al. Response of NBS encoding resistance genes linked to both heat and fungal stress in Brassica oleracea. PLANT PHYSIOLOGY AND BIOCHEMISTRY 86:130-136(2015).
- Faisal, M; Waseem, D; et al. A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. COMPUTERS IN BIOLOGY AND MEDICINE 53:250-257(2014).
