NFE2L3
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Official Full Name
nuclear factor (erythroid-derived 2)-like 3 -
Overview
This gene encodes a member of the cap n collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. -
Synonyms
NFE2L3;nuclear factor (erythroid-derived 2)-like 3;nuclear factor erythroid 2-related factor 3;Nrf3;erythroid derived 2;like 3;NF-E2-related factor 3;NF2L3_HUMAN;NFE2-related factor 3;Nuclear factor;nuclear factor, erythroid derived 2, like 3;nuclear factor-erythroid 2-related factor 3;nuclear factor-erythroid 2 p45-related factor 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFE2L3-1277H | Recombinant Human NFE2L3, GST-tagged | E.coli | Human | GST | 347-694aa | |
| NFE2L3-187H | Recombinant Human NFE2L3 Protein, His-tagged | E.coli | Human | His | 347-694 aa | |
| NFE2L3-3386H | Recombinant Human NFE2L3 protein, His-tagged | E.coli | Human | His | 74-258 aa | |
| NFE2L3-12433Z | Recombinant Zebrafish NFE2L3 | Mammalian Cell | Zebrafish | His |
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Involved Pathway
NFE2L3 involved in several pathways and played different roles in them. We selected most pathways NFE2L3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NFE2L3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NFE2L3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NFE2L3 itself. We selected most functions NFE2L3 had, and list some proteins which have the same functions with NFE2L3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPYD,CDK9,IFIH1,SH2D3C,FAF1,TEKT4,HDLBP,PLSCR4,XRCC5,NAPA |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | HMGA2,MYPOP,NKX3-2,SALL1,KCNIP3,TCF21,NKX6-2,GFI1,REST,PROX1A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX2,ZNF114,CHD7,EN1,CC2D1A,ZNF664,TFE3A,MZF1,GCM1,NFYC |
| transcription factor activity, sequence-specific DNA binding | HSFX1,MAFG,NEUROG1,FOXN2,RORA,ZNF92,FOXF2A,FOXD4,KLF4,EGR2A |
| transcription regulatory region sequence-specific DNA binding | NFE2L2B,NFE2L1B,FOXN1,EPAS1B,BTBD8,TBX18,CRY2,ZNF658,GATA1,EGR1 |
| transcription coactivator activity | ESR2,MED6,SUB1A,IL31RA,BRD7,ING4,WWC1,CDK7,EP300,TFDP1 |
Interacting Protein
NFE2L3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFE2L3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFE2L3.
MAFG;ATF4;NFE2
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