NFE2L2
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Official Full Name
nuclear factor, erythroid 2-like 2 -
Overview
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
NFE2L2;nuclear factor, erythroid 2-like 2;NRF2;nuclear factor erythroid 2-related factor 2;HEBP1;NFE2-related factor 2;NF-E2-related factor 2;nuclear factor erythroid-derived 2-like 2;nuclear factor (erythroid-derived 2)-like 2;nuclear factor, erythroid derived 2, like 2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Rat
- Chicken
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- His&MBP
- DDK&Myc
- GST
- Avi&Fc&His
- Flag
- GST&His
- His&T7
Involved Pathway
NFE2L2 involved in several pathways and played different roles in them. We selected most pathways NFE2L2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFE2L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | DNAJC3A,TXNDC5,SVIP,MBTPS1,CUL1B,SEC61G,ATF6,XBP1,CALR,BAG1 |
Protein Function
NFE2L2 has several biochemical functions, for example, DNA binding,RNA polymerase II activating transcription factor binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFE2L2 itself. We selected most functions NFE2L2 had, and list some proteins which have the same functions with NFE2L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TCF3,NR4A2A,ZNF584,ZNF37A,ZNF454,PGBD1,ZFP746,SFPI1,RB1,SOX21 |
| RNA polymerase II activating transcription factor binding | LMO2,CREBBP,NCOR1,SMAD3,BHLHE40,NEUROD1,HEY2,SETD3,POU1F1,ZFPM1 |
| transcription regulatory region sequence-specific DNA binding | DDIT3,NFKB1,HIF1AL,SOX12,SIN3A,GATA1,SUV39H2,FOXN1,SOX2,NR5A5 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | ARX,BACH1A,PROP1,SFPQ,RUVBL2,SIX3,NFATC1,SFPI1,RXRB,ATF2 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | MIXL1,FOXH1,SIX3,SIX6,SPI1,CUX1,HMGA1,POU4F1,NFATC1,HCFC1 |
| protein binding | LRRC20,TSSK1,CIB2,DNAJC15,USP19,PGBD1,IL2RB,UBE2N,KCNJ6,BBS12 |
| transcription regulatory region DNA binding | DDIT3,BCOR,GATA6,NKX3-1,MEN1,ZFP335,RREB1,CREB3L1,AHR,ZNF174 |
| DNA binding | GTF2I,NR1I3,ABI2,ZNF705B,SP110,NPAS1,TCEANC2,SOX1A,FOXA2,SMYD1 |
| protein domain specific binding | HOXB1,VPS11,YWHAG1,ARHGEF4,KCTD13,TRIM11,XPO1,IKBKG,NDE1,DRD3 |
Interacting Protein
NFE2L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFE2L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFE2L2.
KEAP1;MAFG
Resources
Research Area
NeuroinflammationTranscription Regulators in Endothelial Cells
Alzheimer's Disease
Epithelial Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Neural Stem Cell Markers
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References
