NEUROD1
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Official Full Name
neuronal differentiation 1 -
Overview
NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG. Neuronal activity results in CaMKII-mediated phosp -
Synonyms
NEUROD1;neuronal differentiation 1;NEUROD, neurogenic differentiation 1;neurogenic differentiation factor 1;beta cell E box transactivator 2;BETA2;BHF 1;bHLHa3;MODY6;NeuroD;neurogenic helix loop helix protein NEUROD;beta-cell E-box transactiva
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His&T7
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
NEUROD1 involved in several pathways and played different roles in them. We selected most pathways NEUROD1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEUROD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | FOXA3,NKX6-1,PKLR,NKX6,MAFA,HNF1A,IAPP,HES1,FOXA2,PAX6 |
Protein Function
NEUROD1 has several biochemical functions, for example, E-box binding,RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEUROD1 itself. We selected most functions NEUROD1 had, and list some proteins which have the same functions with NEUROD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TFDP1B,FUS,LPIN2,NFKBIB,RXRA,TAF12,ELF3,CTNNB1,MED31,MTDH |
| RNA polymerase II transcription coactivator activity | MEF2A,NCOA1,MED12,ISL1,TFAP2B,TRIM28,SMARCA4,CITED1,POU3F2,SOX11 |
| contributes_to sequence-specific DNA binding | TRIM28,HIF1A,SMAD4,HNRNPAB,ARNT,PPARG,FIGLA,HDAC4,EPAS1,TCF3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFIB,CREB1,TCF4,NFIC,JUN,NR1H4,PLAG1,SOX4,HEYL,FOXA1 |
| chromatin binding | ATAD2,STAG1,MCMBP,YBX1,LDB1,UBTF,UBTFL,PHF21B,MTA1,CENPA |
| protein binding | CENPA,EEF1A2,PNKD,USP54,KCNE1,ZFPM2A,ORAI1,PRIMPOL,MUTYH,Ccl27a |
| E-box binding | PER1,ZEB1,NEUROG1,MYOG,CLOCK,MYC,ARNTL2,MYOD1,AHR,TFAP4 |
| protein heterodimerization activity | AHR,NAE1,H2AFJ,UNC13A,GCA,UGT1A3,ALX4,OSTB,BCL2A1,CENPW |
| RNA polymerase II activating transcription factor binding | ATF2,TBX6,SIN3A,TBX3,NFE2L2,LMO2,SMAD3,ISL1,EP300,HIPK2 |
Interacting Protein
NEUROD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEUROD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEUROD1.
DUSP3
Resources
Research Area
Pancreatic Endoderm Cell MarkersWnt Signaling Modulators
Neural Stem Cell Transcription Factors
Neural Stem Cell Markers
Neuronal Lineage Markers
Endodermal Lineage Markers
Related Services
Related Products
References
- Akazawa, N; Kawachi, H; et al. Neuroendocrine carcinoma of the esophagus: clinicopathologic study of 10 cases and verification of the diagnostic utility of mASH1, NeuroD1, and PGP9.5. ESOPHAGUS 11:245-257(2014).
- Benitez, SG; Castro, AE; et al. Hypoxic Preconditioning Differentially Affects GABAergic and Glutamatergic Neuronal Cells in the Injured Cerebellum of the Neonatal Rat. PLOS ONE 9:-(2014).
