NEK3
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Official Full Name
NIMA (never in mitosis gene a)-related kinase 3 -
Overview
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NEK3;NIMA (never in mitosis gene a)-related kinase 3;serine/threonine-protein kinase Nek3;glycogen synthase A kinase;HSPK36;hydroxyalkyl protein kinase;MGC29949;phosphorylase B kinase kinase;serine/threonine protein kinase NEK3;HSPK 36;hydroxyal
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NEK3-924M |
Recombinant Mouse NEK3 protein(Met1-Ala509), His&GST-tagged
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Insect Cells | Mouse | His&GST | 1-509 a.a. |
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| NEK3-29620TH | Recombinant Human NEK3 | Human | Non | Full L. 1-506 a.a. |
|
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| NEK3-369H | Recombinant Human NEK3, GST-tagged, Active | Sf9 Insect Cell | Human | GST |
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| NEK3-446MCL | Recombinant Mouse NEK3 cell lysate | Insect Cell | Mouse | Non |
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| NEK3-7074HF | Active Recombinant Full Length Human NEK3 Protein, GST-tagged | Insect (sf21) | Human | GST | Full L. 1-506 |
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Involved Pathway
NEK3 involved in several pathways and played different roles in them. We selected most pathways NEK3 participated on our site, such as Prolactin Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prolactin signaling pathway | RELA,SHC1,SOCS2,MAPK3,SHC4,PRLR,NFKB1,AKT2,LHB,RAF1 |
Protein Function
NEK3 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK3 itself. We selected most functions NEK3 had, and list some proteins which have the same functions with NEK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZBTB33,Chrng,ERO1LB,PTPRC,MT2A,WDR61,NUDCD3,PPIL2,ARNTL1B,VGLL2 |
| metal ion binding | TRIM46B,DNLZ,NUDT12,PPP6C,CYP3C1L2,RARAB,LMX1BA,SNAI1,TNNI3,GART |
| protein serine/threonine kinase activity | MAP4K3,CDC42BPA,MAST2,CASK,Aatk,PRKDC,GAK,RIOK3,DSTYK,PIK3CG |
| ATP binding | HSP90AA1,PRKCBB,ACSM2B,CHD7,GRK7A,CDC34B,DGKZ,MAPK8,UBE2G2,UCKL1A |
Interacting Protein
NEK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK3.
PRLR;VAV2;BPGM;CDCA8;NMNAT1
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