NEFM
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Official Full Name
neurofilament, medium polypeptide -
Overview
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] -
Synonyms
NEFM;neurofilament, medium polypeptide;NFM;NEF3;NF-M;neurofilament medium polypeptide;neurofilament 3;160 kDa neurofilament protein;neurofilament triplet M protein;neurofilament-3 (150 kD medium);neurofilament, medium polypeptide 150kDa
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- Bovine
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- bovine Spinal Cord
- Yeast
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- His&Myc
- Myc&DDK
Involved Pathway
NEFM involved in several pathways and played different roles in them. We selected most pathways NEFM participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | ALS2,MAPK14,GRIN2C,BAD,MAPK13,BCL2,PPP3R1,BCL2L1,BAX,PPP3CB |
Protein Function
NEFM has several biochemical functions, for example, microtubule binding,protein binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFM itself. We selected most functions NEFM had, and list some proteins which have the same functions with NEFM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ALDH7A1,TMEM203,CCDC43,E2F3,H1F0,TSPAN6,OLIG3,AHSP,GBA,PPP1CC |
| structural constituent of cytoskeleton | TUBGCP2,CTNNA2,ACTL7A,BFSP1,ARPC1B,ARPC4,EPB41L4B,EPB42,TUBA8L3,EPB41 |
| microtubule binding | BIRC5,PRC1B,CDK5RAP2,PAFAH1B1B,MTAP1B,GAS2L2,KIF7,TRPV4,MAST2,PAFAH1B1 |
Interacting Protein
NEFM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFM here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFM.
RB1;FOS;JUN;ETS1;NR4A2;RAC3;MDM2;SQSTM1;SMAD2;Hap1;TNIK;q9wmx2-pro_0000037548;DNAJA2;PTBP3;CALD1;IQCB1
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References
- Penney, KL; Sinnott, JA; et al. Association of Prostate Cancer Risk Variants with Gene Expression in Normal and Tumor Tissue. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 24:255-260(2015).
- Barboni, B; Russo, V; et al. Gestational stage affects amniotic epithelial cells phenotype, methylation status, immunomodulatory and stemness properties. STEM CELL REVIEWS AND REPORTS 10:725-741(2014).
