NEDD4

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

  • Overview

    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.

  • Synonyms

    NEDD4;neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase;RPF1;NEDD4-1;E3 ubiquitin-protein ligase NEDD4;receptor-potentiating factor 1;cell proliferation-inducing gene 53 protein;neural precursor cell expressed developmentally down-regulated protein 4

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Insect Cell
  • Sf9 Insect Cell
  • HEK293
  • HEK293T
  • GST
  • His
  • Flag
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
NEDD4-1252H Recombinant Human NEDD4, GST-tagged E.coli Human GST C-350aa
NEDD4-2461H Recombinant Human NEDD4 protein, His-tagged E.coli Human His 970-1319 aa
NEDD4-01H Active Recombinant Human NEDD4 protein, His-tagged E.coli Human His
NEDD4-29278TH Recombinant Human NEDD4, FLAG-tagged Insect Cell Human Flag 751 amino acids
NEDD4-520H Recombinant Human NEDD4, FLAG-tagged Sf9 Insect Cell Human Flag 150-end a.a.
NEDD4-3886HCL Recombinant Human NEDD4 293 Cell Lysate HEK293 Human Non
NEDD4-1245H Recombinant Human NEDD4 protein, GST-tagged E.coli Human GST
NEDD4-14H Active Recombinant Human NEDD4 Protein (Leu570-Asp1319), N-6×His-tagged Insect Cell Human His Leu570-Asp1319
Nedd4-4359M Recombinant Mouse Nedd4 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NEDD4-4676H Recombinant Human NEDD4 Protein (Met1-Asp900), N-GST tagged E.coli Human GST Met1-Asp900

    Involved Pathway

    NEDD4 involved in several pathways and played different roles in them. We selected most pathways NEDD4 participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection TP53,TBP,HLA-DRA,SND1,HLA-E,TRAF1,TRAF3,POLR3B,MAP3K14,H2-Q10
    Ubiquitin mediated proteolysis SIAH1,BTRC,UBE2E2,UBE3A,UBE2U,UBE2D2,ANAPC11,CUL3,ITCHA,RHOBTB1
    Endocytosis CSF1R,SMAD2,MDM2,PSD2,CAV2,ARF6,RAB5B,STAMBP,TSG101A,EPN3

    Protein Function

    NEDD4 has several biochemical functions, for example, RNA polymerase binding,beta-2 adrenergic receptor binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4 itself. We selected most functions NEDD4 had, and list some proteins which have the same functions with NEDD4. You can find most of the proteins on our site.

    Function Related Protein
    phosphothreonine binding PIN1
    phosphoserine binding PIN1,YWHAB,YWHAE
    ubiquitin protein ligase activity BRAP,UBE2NA,HECTD1,ITCHA,ANAPC11,ASB4,NEDD4L,CBLC,RNF180,HECW1
    RNA polymerase binding STOM,WDHD1,GSG1,ANP32B,PPIB,TAF10,YTHDC2,PKN2,RRN3,BIN1
    protein binding ERBB2,POLR1A,RPTOR,DNAJC5B,SPSB2,SLIRP,MED25,MAPKAP1,GPR85,KCTD6
    sodium channel inhibitor activity CAMK2D,SLC14A2,SCN1B,PCSK9,NEDD4L
    proline-rich region binding WBP4,ABL1,PRPF40A,CYLD,BAIAP2L1,ABI2,GHR,RABAC1,FAM59A,GAREM
    ligase activity FPGS,PCXB,MID2,RNF125,KCMF1,SMURF2,UBE3A,UCHL1,DTX3L,E4F1
    beta-2 adrenergic receptor binding GNAS,SLC9A3R1,PDE4D,BDKRB2

    Interacting Protein

    NEDD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4.

    SCNN1B;FGFR1

    Resources

    Research Area

    Ubiquitin-related Molecules in the Akt Pathway
    E3 Ubiquitin Ligases

    References

    • Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
    • Mujoo, K; Choi, BK; et al. Regulation of ERBB3/HER3 signaling in cancer. ONCOTARGET 5:10222-10236(2014).

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