NCK2

  • Official Full Name

    NCK adaptor protein 2

  • Overview

    This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

  • Synonyms

    NCK2;NCK adaptor protein 2;cytoplasmic protein NCK2;NCKbeta;SH2/SH3 adaptor protein NCK-beta;growth factor receptor-bound protein 4;noncatalytic region of tyrosine kinase, beta;GRB4

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • His
  • Non
  • His&SUMO
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NCK2-10471M Recombinant Mouse NCK2 Protein Mammalian Cell Mouse His
NCK2-15879H Recombinant Human NCK2, His-tagged E.coli Human His 1-380aa
NCK2-2511C Recombinant Chicken NCK2 Mammalian Cell Chicken His
NCK2-29113TH Recombinant Human NCK2, His-tagged E.coli Human His 199-380 a.a.
NCK2-49H Recombinant Human NCK Adaptor Protein 2 E.coli Human Non
NCK2-3945HCL Recombinant Human NCK2 293 Cell Lysate HEK293 Human Non
NCK2-3946HCL Recombinant Human NCK2 293 Cell Lysate HEK293 Human Non
NCK2-3267H Recombinant Human NCK2 protein, His-SUMO-tagged E.coli Human His&SUMO 1-380aa
Nck2-4311M Recombinant Mouse Nck2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NCK2-5136H Recombinant Human NCK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
NCK2-5941M Recombinant Mouse NCK2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
NCK2-5941M-B Recombinant Mouse NCK2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    NCK2 involved in several pathways and played different roles in them. We selected most pathways NCK2 participated on our site, such as ErbB signaling pathway,Axon guidance,T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance DPYSL4,LRRC4C,KDR,FGFR1B,EPHA2A,PITPNA,AP2A1,NTN1B,DLG4,RHOA
    ErbB signaling pathway SHC4,AREGB,BADB,RPS6KB1B,RPS6KB2,MAPK8A,NCK2B,MAP2K2,PAK2,AKT2L
    T cell receptor signaling pathway GRB2,VAV1,MAP2K7,DBNLB,CBLC,CD247,FOS,PRKCQ,MAP2K2,HRAS
    Pathogenic Escherichia coli infection NCL,ARHGEF2,PRKCA,CDC42,HCLS1,TUBAL3,ACTB,TUBA1A,ARPC5L,CD14

    Protein Function

    NCK2 has several biochemical functions, for example, SH3/SH2 adaptor activity,cytoskeletal adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCK2 itself. We selected most functions NCK2 had, and list some proteins which have the same functions with NCK2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TRIM5,FDX1L,KPNA4,SRSF10,CAML,ASF1A,PECAM1,CHIC2,TMEM8B,ROPN1L
    protein complex binding PPP2R2A,PPFIA2,PPARA,ABI2,UQCRFS1,CPS1,INS2,KAT2B,ATP6V0D1,FLCN
    receptor signaling complex scaffold activity GRIP2A,CD3G,GRIP1,MAPK8IP3,DEDD2,CD3E,MAGI2,LRRK2,RGS14,SPAG9A
    cytoskeletal adaptor activity BIN3,GAS2L2,ABI2,BAIAP2L2B,BAIAP2,BAIAP2L1B,GAS2L1,NCK1,ANK1,SDCBP
    scaffold protein binding CACNA1G,KRT8,PDE4D,NOS3,HOMER1,SHANK1,MDM2,CAV2,KRT18,PANX1
    SH3/SH2 adaptor activity LAT,SHB,STAM,SH3BGR,SH3BGRL,CHN1,SH3BP2,SKAP2,SLA2,SH2D1A

    Interacting Protein

    NCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCK2.

    RHOU;CHN1;PAK1;CBLB

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