NCAN
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Official Full Name
neurocan -
Overview
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and;migration. -
Synonyms
NCAN;neurocan;chondroitin sulfate proteoglycan 3 , CSPG3;neurocan core protein;neurocan proteoglycan;chondroitin sulfate proteoglycan 3 (neurocan);CSPG3;FLJ44681
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- CHO
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- His&Fc&Avi
Involved Pathway
NCAN involved in several pathways and played different roles in them. We selected most pathways NCAN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,Axon guidance,CS/DS degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | GPC1A,AGRN,CSPG4,VCANB,B3GAT2,VCAN,GPC5A,GPC6,BCAN,GPC1B |
| Defective B4GALT7 causes EDS, progeroid type | DCN,CSPG5,BGN,GPC5,BCAN,GPC6,VCAN,AGRN,CSPG4 |
| chondroitin sulfate biosynthesis | BGNB,VCANB,B3GAT2,VCAN,CSPG5B,BGNA,UST,CSPG4,BGN,BCAN |
| Axon guidance | NRTN,GFRA1,FRS3,SPRED2,CREB1B,PLXNA3,MYL12B,EPHB6,CD24,NADL1.1 |
| CS/DS degradation | DCN,BGN,BCAN,BGNA,CSPG4,VCANB,BGNB,VCAN,CSPG5B,CSPG5 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | GPC5,BGN,GPC6,CSPG5,DCN,AGRN,VCAN,BCAN,CSPG4 |
| Defective B3GAT3 causes JDSSDHD | VCAN,AGRN,BCAN,GPC6,DCN,GPC5,CSPG5,CSPG4,BGN |
| Chondroitin sulfate/dermatan sulfate metabolism | VCANB,GPC5A,AGRN,GPC1A,DSEL,CSPG4,GPC1B,B4GALT7,CSPG5,BGN |
Protein Function
NCAN has several biochemical functions, for example, calcium ion binding,carbohydrate binding,hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCAN itself. We selected most functions NCAN had, and list some proteins which have the same functions with NCAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | BGLAP-RS1,NUCB2B,SLC25A13,MFGE8B,CRB2A,CDHR3,CAPRIN1A,SLC25A23,BMP1B,SYTL3 |
| hyaluronic acid binding | HMMR,HYAL2,HAPLN1,HAPLN4,HAPLN1A,HAPLN2,ACAN,C1QBP,LAYN,STAB2 |
| carbohydrate binding | GALNTL6,VCAN,KLRF1,LGALSL,CD302,CD248,POC1BL,GANAB,CD22,CLEC4D |
Interacting Protein
NCAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCAN here. Most of them are supplied by our site. Hope this information will be useful for your research of NCAN.
q9wmx2-pro_0000037548
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References
- Iseki, K; Hagino, S; et al. Gliosis-specific transcription factor OASIS coincides with proteoglycan core protein genes in the glial scar and inhibits neurite outgrowth. BIOMEDICAL RESEARCH-TOKYO 33:345-353(2012).
- Yi, JH; Katagiri, Y; et al. Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice. JOURNAL OF COMPARATIVE NEUROLOGY 520:3295-3313(2012).
