NAT2
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Official Full Name
N-acetyltransferase 2 (arylamine N-acetyltransferase) -
Overview
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). -
Synonyms
NAT2;N-acetyltransferase 2 (arylamine N-acetyltransferase);AAC2;arylamine N-acetyltransferase 2;ARY2_HUMAN;Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation);Arylamide acetylase 2;HGNC:7646;N-acetyltransferase type 2;NAT-2;PNAT;Polymorphic arylamine N-acetyltransferase;OTTHUMP00000161399;OTTHUMP00000224593
Recombinant Proteins
- Rat
- Mouse
- Rhesus macaque
- Human
- E.coli
- Mammalian Cells
- Wheat Germ
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- SUMO
- Avi
- Fc
Involved Pathway
NAT2 involved in several pathways and played different roles in them. We selected most pathways NAT2 participated on our site, such as Acetylation,Arylamine metabolism,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Caffeine metabolism | NAT1,UOX,CYP1A2,PNAT3,XDH,Nat3,NAT,PNAT10,CYP2A6 |
| Metabolic pathways | FUT1,BCMO1,UCK1,ALOX8,NDUFS8A,ALOX12E,TUSC3,ST3GAL3,ST6GALNAC1,SPRA |
| Chemical carcinogenesis | SULT1A2,GSTT2,CYP1A1,MGST1,ALDH3A1,HSD11B1,GSTM5,ARNT,CYP3A41A,ADH6 |
| Arylamine metabolism | CYP1A2 |
| Biological oxidations | FDX1,CYP2V1,CYP24A1,DPEP1,SULT1ST5,MTRR,ADH8B,GSTO2,CYP2N13,UGT1B2 |
| Metabolism | AMD2,PPM1LA,SULT1B1,NUBP2,MED29,CYP2Y3,CYGB2,MED16,PNPLA8,NUDT10 |
| Drug metabolism - other enzymes | TYMP,UCKL1,IMPDH1,UGT1A3,UGT1A1,UGT1A7,IMPDH1A,UCK1,CES1,TK2 |
Protein Function
NAT2 has several biochemical functions, for example, arylamine N-acetyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT2 itself. We selected most functions NAT2 had, and list some proteins which have the same functions with NAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FARSA,UNC45A,FCNA,TRAPPC2L,PRSS2,CRKL,COX4I1,CXADR,GCHFR,HIPK4 |
| arylamine N-acetyltransferase activity | AANAT,PNAT3,NAT,PNAT10,Nat3 |
Interacting Protein
NAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT2.
RAD51;ATM;AURKA;PPM1D;NBN;HMMR;BAG4;ERBB2;IGF1R;CDH1;WT1;APC;CDKN2A;CDKN2C;STK11;PALB2
Resources
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References
- Mikuls, TR; LeVan, T; et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. ARTHRITIS AND RHEUMATISM 64:655-664(2012).
- Littorin, M; Hou, S; et al. Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 81:429-441(2008).
