NAT1
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Official Full Name
N-acetyltransferase 1 (arylamine N-acetyltransferase) -
Overview
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NAT1;N-acetyltransferase 1 (arylamine N-acetyltransferase);AAC1;arylamine N-acetyltransferase 1;ARY1_HUMAN;Arylamide acetylase 1;Arylamine N acetyltransferase 1;MNAT;Monomorphic arylamine N acetyltransferase;Monomorphic arylamine N-acetyltransferase;N acetyltransferase type 1;N-acetyltransferase type 1;NAT 1;NAT-1;NATI;OTTHUMP00000122488;OTTHUMP00000224577;OTTHUMP00000224578;OTTHUMP00000224579
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- E.Coli/Yeast
- In Vitro Cell Free System
- HEK293
- His
- Non
- Fc
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Nat1-405M | Recombinant Mouse Nat1 Protein, His-tagged | E.coli | Mouse | His | Arg9~Glu254 | |
| NAT1-10434M | Recombinant Mouse NAT1 Protein | Mammalian Cells | Mouse | His |
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| NAT1-138H | Recombinant Human NAT1 Protein, His-tagged | E.coli | Human | His |
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| NAT1-28863TH | Recombinant Human NAT1 | Wheat Germ | Human | Non | 290 amino acids |
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| NAT1-30282TH | Recombinant Human NAT1, His-tagged | E.coli | Human | His | 290 amino acids |
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| NAT1-30283TH | Recombinant Human NAT1, Fc-tagged | Wheat Germ | Human | Fc | 90 amino acids |
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| NAT1-3573H | Recombinant Human NAT1, His-tagged | E.coli | Human | His |
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| Nat1-3653M | Recombinant Mouse Nat1, His-tagged | E.Coli/Yeast | Mouse | His | 290 |
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| NAT1-3906R | Recombinant Rat NAT1 Protein | Mammalian Cells | Rat | His |
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| NAT1-1168HCL | Recombinant Human NAT1 cell lysate | Human | Non |
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| NAT1-1817H | Recombinant Human NAT1 Protein, His&GST-tagged | E.coli | Human | His&GST | Asp20-Val280 |
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| NAT1-2478H | Recombinant Human NAT1 Protein, His-tagged | E.coli | Human | His | Asp20-Val280 |
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| NAT1-328HF | Recombinant Full Length Human NAT1 Protein | In Vitro Cell Free System | Human | Full L. 290 amino acids |
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| NAT1-3565R | Recombinant Rat NAT1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NAT1-3565R-B | Recombinant Rat NAT1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| NAT1-5915M | Recombinant Mouse NAT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NAT1-5915M-B | Recombinant Mouse NAT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NAT1 involved in several pathways and played different roles in them. We selected most pathways NAT1 participated on our site, such as Caffeine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Caffeine metabolism | NAT2,CYP1A2,PNAT3,XDH,Nat3,NAT,CYP2A6,UOX,PNAT10 |
| Chemical carcinogenesis | CYP3A4,AKR1C2,AHA-1,CBR1,GSTM4,UGT1A6A,GSTO1,ARNT,GSTM2,ALDH1A3 |
| Drug metabolism - other enzymes | NAT,IMPDH2,XDH,UPP1,DPYS,UGT1A2,UGT2A2,PNAT10,UGT1A6B,CES2 |
| Metabolic pathways | GALNTL6,MAN2A1,CPOX,NNT,RDH8,SDHA,NT5C3B,BHMT,AMY1B,NDUFC1 |
Protein Function
NAT1 has several biochemical functions, for example, ATP binding,cyclin-dependent protein serine/threonine kinase activity,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT1 itself. We selected most functions NAT1 had, and list some proteins which have the same functions with NAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | UBE2KA,MYH3,PDGFRB,TSSK3,PL10,SRR,ACTB1,PRKCH,PGK1,GCLC |
| cyclin-dependent protein serine/threonine kinase activity | CDK13,CDKL5,CDK10,CCND3,CDKL4,CDK16,CDK4,CDK3,MAK,MOK |
| protein kinase activity | SRPK1A,STK24,CSNK2A2A,SCYL1,PAK1,FYNA,PLK1,GUCY2C,PPP1R9B,PRKG2 |
Interacting Protein
NAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT1.
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References
- Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
- Mikuls, TR; LeVan, T; et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. ARTHRITIS AND RHEUMATISM 64:655-664(2012).
