NANS
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Official Full Name
N-acetylneuraminic acid synthase -
Overview
Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. -
Synonyms
NANS;N-acetylneuraminic acid synthase;sialic acid synthase;SAS;EC 2.5.1.56;EC 2.5.1.57;N acetylneuraminate 9 phosphate synthase;N acetylneuraminate synthase;N acetylneuraminic acid phosphate synthase;N acetylneuraminic acid synthase;OTTHUMP00000
Recombinant Proteins
- Chicken
- Human
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Mouse
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
NANS involved in several pathways and played different roles in them. We selected most pathways NANS participated on our site, such as Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NANS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CBR1L,MAT1A,UPRT,P4HA3,COX6B2,FUT3,CDS2,CYP21A2,UGT5G1,CERS2A |
| Amino sugar and nucleotide sugar metabolism | MPI,HEXA,GKUP,GPI1,PGM3,UXS1,UGP2B,GNPNAT1,GFPT1,CHIA.3 |
Protein Function
NANS has several biochemical functions, for example, N-acetylneuraminate synthase activity,N-acylneuraminate cytidylyltransferase activity,N-acylneuraminate-9-phosphate synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NANS itself. We selected most functions NANS had, and list some proteins which have the same functions with NANS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acylneuraminate cytidylyltransferase activity | CMASB,CMASA,CMAS |
Interacting Protein
NANS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NANS here. Most of them are supplied by our site. Hope this information will be useful for your research of NANS.
DDA1;TNIK;AURKA;BUB1;TLR2;BCL10;EGFR;ODC1;CDH1;SRC;MCC;APC;CTNNA1;MSH6;PTPRJ;PDGFRL;STK11;FLCN;FBXW7;MLH3
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References
- Castilho, A; Pabst, M; et al. Construction of a functional CMP-sialic acid biosynthesis pathway in arabidopsis. PLANT PHYSIOLOGY 147:331-339(2008).
- Gracheva, EV; Samovilova, NN; et al. Enhancing of GM3 synthase expression during differentiation of human blood monocytes into macrophages as in vitro model of GM3 accumulation in atherosclerotic lesion. MOLECULAR AND CELLULAR BIOCHEMISTRY 330:121-129(2009).
