MYO6

  • Product List
  • Overview
  • Review / Q&A

  • Official Full Name

    myosin VI

  • Overview

    This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.

  • Synonyms

    MYO6;myosin VI;deafness, autosomal recessive 37 , DFNA22, DFNB37;myosin-VI;KIAA0389;Deafness autosomal recessive 37;DFNA 22;DFNA22;DFNB 37;DFNB37;MYO 6;MYO6_HUMAN;Myosin 6;Myosin6;MyosinVI;Unconventional myosin-6

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYO6-3372H Recombinant Human MYO6 protein, His-tagged E.coli Human His 1-145 aa
MYO6-2927R Recombinant Rhesus monkey MYO6 Protein, His-tagged Mammalian Cells Rhesus macaque His
MYO6-502H Recombinant Human MYO6 Mammalian Cells Human His
MYO6-6300C Recombinant Chicken MYO6 Mammalian Cells Chicken His
MYO6-4006HCL Recombinant Human MYO6 293 Cell Lysate HEK293 Human Non
MYO6-2746R Recombinant Rhesus Macaque MYO6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MYO6-2746R-B Recombinant Rhesus Macaque MYO6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MYO6-3564H Recombinant Human MYO6 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
MYO6-3564H-B Recombinant Human MYO6 Protein Pre-coupled Magnetic Beads HEK293 Human
Myo6-4260M Recombinant Mouse Myo6 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MYO6-4814H Recombinant Human MYO6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MYO6-5843H Recombinant Human MYO6 Protein, GST-tagged Wheat Germ Human GST

Involved Pathway

MYO6 involved in several pathways and played different roles in them. We selected most pathways MYO6 participated on our site, such as Gap junction degradation,Gap junction trafficking,Gap junction trafficking and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Stabilization and expansion of the E-cadherin adherens junction LIMA1,LPP,PLEKHA7,KIFC3
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity GRIP1,CACNG2,HAND2,NSFB,AKAP5,CACNG3,NSFA,PICK1
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell DLG1L,CHRNA5,CHRND,NSFB,HAND2,GRIP1,NCALDA,CHRNA2,NSFA,AKAP5
Membrane Trafficking SEC16B,CTSZ,TRAPPC4,SCFD1,SNF8,COPE,TPD52L1,TFR1B,LMAN2,DTNBP1
Neuronal System CACNG2B,KCNB1,SLC6A1B,PICK1,DLG1L,CHRNA2,LIN7C,SLC6A11,CHRND,KCNH1
Gap junction trafficking and regulation GJB3,CX27.5,GJB7,GJD3,GJB5,GJA8,GJC1,GJB4,MYO6A,GJA5
Gap junction trafficking MYO6A,GJB5,GJB7,GJA4,GJB2,GJB4,GJA8,DAB2,GJB3,GJC1
Gap junction degradation MYO6A,MYO6B,DAB2

Protein Function

MYO6 has several biochemical functions, for example, ADP binding,ATP binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO6 itself. We selected most functions MYO6 had, and list some proteins which have the same functions with MYO6. You can find most of the proteins on our site.

Function Related Protein
ATP binding ACSM4,AK7A,DDX20,OLA1,PDK1,DDX18,PRPS1,ZAP70,MYH13,ETNK2
actin binding PARK2,FSCN2,ABLIM1,LIMCH1A,TBC1D21,FKBP15,GSNB,KCNMA1,GC,SCINLA
ADP binding MYO3A,APAF1,PRPS1,PKM,MYH10,PRKAG1,VCP,ME1,MIEF1,LONP1
calmodulin binding EEF2K,CAMKV,KCNH1,MYO1D,CAMK1GA,DCX,KCNN1A,MYH4,USP6,CAMSAP1
actin filament binding TRPV4,SSFA2,WIPF1A,GAS7,TRIOBPB,AIF1,TLN2A,AASS,SMYHC2,VIL1
protein binding UIMC1,HIST1H4E,SLC9A7,CASP8,DYRK1B,UBE2L6,CD40,TBKBP1,CDC42EP2,RDBP
motor activity DNAIC2,SMYHC2,MYH9A,DYNLT1,MYL6,DYNLL1,VMHCL,KIF1C,MYH11A,DNAHC8

Interacting Protein

MYO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO6.

Dab2;DAB2;UBB;GIPC1;TNFRSF1A;TNFRSF1B;USP11;AP2B1;Dab1;IKBKE;MAP3K3;CYLD;USP25;RIPK3;IKBKG

Resources

References

  • Zak, M; Bress, A; et al. Ergic2, a Brain Specific Interacting Partner of Otoferlin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29:941-948(2012).

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