MYLK

  • Official Full Name

    myosin light chain kinase

  • Overview

    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3 region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

  • Synonyms

    MYLK;myosin light chain kinase;myosin, light polypeptide kinase;myosin light chain kinase, smooth muscle;MLCK;MLCK1;MYLK1;smMLCK;smooth muscle myosin light chain kinase;telokin;kinase-related protein;KRP;AAT7;MLCK108;MLCK210;MSTP083;FLJ122

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST&His
  • His&T7
  • Non
  • GST
  • His
  • DDK&Myc
  • His&Myc&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYLK-1509H Recombinant Human MYLK protein, His & GST-tagged E.coli Human GST&His Phe1661~Asp1877
Mylk-1510M Recombinant Mouse Mylk protein, His & T7-tagged E.coli Mouse His&T7 Met1684~Asp1884
MYLK-27838TH Recombinant Human MYLK Human Non 1425-1776 a.a.
MYLK-355H Recombinant Human Myosin Light Chain Kinase, GST-tagged, Active Sf9 Cells Human GST 1425-1776 a.a.
MYLK-696H Recombinant Human Myosin Light Chain Kinase, GST-tagged Insect Cells Human GST 1428-1771 a.a.
MYLK-7009C Recombinant Chicken MYLK Mammalian Cells Chicken His
MYLK-4017HCL Recombinant Human MYLK 293 Cell Lysate HEK293 Human Non
Mylk-335M Recombinant Mouse Mylk Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
Mylk-3878C Recombinant Chicken Mylk protein, His-SUMO & Myc-tagged E.coli Chicken His&Myc&SUMO 1435-1722aa
MYLK-4651H Recombinant Human MYLK Protein (Thr1748-Glu1914), N-His tagged E.coli Human His Thr1748-Glu1914
MYLK-4858H Recombinant Human MYLK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MYLK-5820H Recombinant Human MYLK Protein, GST-tagged Wheat Germ Human GST
MYLK-5954H Recombinant Human MYLK protein, His-tagged E.coli Human His 1464-1719aa
MYLK-6768HF Recombinant Full Length Human MYLK Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 992 amino acids

    Involved Pathway

    MYLK involved in several pathways and played different roles in them. We selected most pathways MYLK participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion FYNB,FLNB,MYL9A,ITGA6,ACTB,PIK3R1,FLT1,ACTN3B,PRKCG,PXN
    Regulation of Actin Cytoskeleton FGF9,Pdgfa&Pdgfb,SLC9A1,PAK7,FGF18A,PDGFB,MYL12.1,ITGA11A,RRAS,LIMK1A
    Gastric acid secretion PRKACB,CAMK2D,ATP1B3,CAMK2B,KCNE2,ATP1A2,GAST,EZR,PRKCA,PLCB3
    cGMP-PKG signaling pathway PPP1CC,RGS2,GNAQ,ATP2B4,GNA12,MAP2K2,SLC25A6,NPR1,CREB5,GTF2IRD1
    Calcium signaling pathway RYR3,MYLK3,SLC8A1,CHRM5A,AGTR1,PHKB,ADORA2AB,MYLK2,TNNC1,P2RX7
    Oxytocin signaling pathway MYLK2,CAMK2B,ELK1,CALML3,CACNG6,EEF2K,ROCK1,PIK3R5,CAMK2A,NFATC2
    Platelet activation STIM1,MYLK3,LCP2,SRC,PPP1CB,GNAI2,MAPK3,FERMT3,ITPR3,GP5
    Vascular smooth muscle contraction PLA2G6,PLCB1,PLA2G12A,PRKCBA,ROCK2,CALM2A,ROCK2A,CYP4A12A,GNA13A,ADCY1A

    Protein Function

    MYLK has several biochemical functions, for example, ATP binding,actin binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK itself. We selected most functions MYLK had, and list some proteins which have the same functions with MYLK. You can find most of the proteins on our site.

    Function Related Protein
    myosin light chain kinase activity MYLK2,MYLK3
    calmodulin binding ENKUR,MAP6,CAMK2D1,SLC8A2,SCN5A,RYR1,MKNK2,CAMK2D,PCP4,DCX
    ATP binding BAT1,ITPK1A,LIMK1,CAMK2B,EPHB3,SRC,ACSBG2,PIP4K2B,GRK7,DNAH6
    protein binding SAP30BP,UCHL3,USP42,BLOC1S1,CRB3,NR1D2,PLAUR,NPEPL1,DUSP21,NRBP1
    actin binding SMYHC3,MTAP1B,MSNA,ABLIM1,CCDC88A,RUSC1,SCIN,NRAP,MYO1C,VPS18
    metal ion binding ZNF234,SNRNP48,ACAP3B,ATP8B1,MMP1A,COPS5,TRIM55B,ZBTB8B,ERI3,CECR1A

    Interacting Protein

    MYLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK.

    GOPC;MYL12A;NCK1;PIK3R1;GRB2;CTTN;HSPB1;q7ard3_yerpe;q7cje7_yerpe;ahpC;exuR;tbpA1;q8d0g3_yerpe;npm_alk

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