MYH3
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Official Full Name
myosin, heavy chain 3, skeletal muscle, embryonic -
Overview
Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba. -
Synonyms
embryonic;fast skeletal muscle;HEMHC;Muscle embryonic myosin heavy chain 3;Muscle embryonic myosin heavy chain;MYH 3;MYH3;MYH3_HUMAN;MYHC EMB;MYHSE 1;MYHSE1;Myosin heavy chain 3;Myosin heavy chain 3 skeletal muscle embryonic;Myosin heavy chain;Myosin heavy chain fast skeletal muscle embryonic;Myosin Heavy Polypeptide 3;Myosin heavy polypeptide 3 skeletal muscle embryonic;Myosin skeletal heavy chain embryonic 1;Myosin-3;SMHCE;embryonic myosin
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
MYH3 involved in several pathways and played different roles in them. We selected most pathways MYH3 participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | PRKCBB,PRKCE,RHOAA,MYLPF,MYLPFB,SPTAN1,PARD6GA,NRAS,PRKCB,MYH8 |
Protein Function
MYH3 has several biochemical functions, for example, ATP binding,ATPase activity, coupled,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH3 itself. We selected most functions MYH3 had, and list some proteins which have the same functions with MYH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | GM101,PDE1B,CNN1,DAPK2,MYO5C,EEF2K,SPHK1,MYH10,ATP2B1,INVS |
| microfilament motor activity | MYH13,MYH7,MYH9,MYO5A,STRC,MYH8,MYO7A,MYO3B,MYO9B,MYO5B |
| ATP binding | FES,PLK2B,CSNK1G2B,PIP4K2C,TAOK3,SMYHC3,TRIT1,ATP1A3,MKNK2,DDX43 |
| ATPase activity, coupled | HSPA6,MYO1E,VPS4B,CCT8,PEX1,ABCB1A,VPS4A,HSPA8,NSF,HSPA1A |
| actin filament binding | MAP1S,TTN,EZR,AIF1L,SYNE1,ERMN,ANTXR1,TRIOBPB,MYH11,LASP1 |
Interacting Protein
MYH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH3.
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