MVD
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Official Full Name
mevalonate (diphospho) decarboxylase -
Overview
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. -
Synonyms
MVD;mevalonate (diphospho) decarboxylase;diphosphomevalonate decarboxylase;mevalonate pyrophosphate decarboxylase;MPD;FP17780;MDDase;Mevalonate (diphospho)decarboxylase;MVD1_HUMAN;OTTHUMP00000175197;mevalonatepyrophosphate decarboxylase
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
MVD involved in several pathways and played different roles in them. We selected most pathways MVD participated on our site, such as Terpenoid backbone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MVD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | ZMPSTE24,MVDA,IDI2,HMGCRB,HMGCS2,GGPS1,MVK,ICMT,ACAT2,ACAT1 |
| Metabolic pathways | B3GNT1,NT5C3A,IPPK,PHGDH,TPI1A,ASPA,UGCG,NOS1,PFKP,GGT6 |
Protein Function
MVD has several biochemical functions, for example, ATP binding,Hsp70 protein binding,diphosphomevalonate decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MVD itself. We selected most functions MVD had, and list some proteins which have the same functions with MVD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diphosphomevalonate decarboxylase activity | MVDA |
| protein homodimerization activity | CEBPA,ZBTB1,PRPS1,DNM1L,RRAGA,PRDM6,HRSP12,SPPL2B,GPD1A,XDH |
| ATP binding | DYRK1A,CDK12,HSPA4A,DDX39AA,CKMT1,NDUFA13,ACVR2B,ADCY1,RTCD1,NME1 |
| Hsp70 protein binding | TSACC,ERN1,PARK2,METTL21A,BAG6,DNAJB1,PACRG,RNF207,STUB1,C11orf73 |
Interacting Protein
MVD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MVD here. Most of them are supplied by our site. Hope this information will be useful for your research of MVD.
GNB5;EEF1G;EIF4EBP1;CDK1;CTBP2;LRIF1;Med22;Smc3;SETD1B
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References
- Wang, WJ; Sivakumar, W; et al. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. NEUROSURGICAL FOCUS 38:-(2015).
- Zhang, J; Yang, JM; et al. Multiple antigenic polypeptide composed of heparanase B-cell epitopes shrinks human hepatocellular carcinoma in mice. ONCOLOGY REPORTS 33:1248-1256(2015).
