MTHFR
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Official Full Name
methylenetetrahydrofolate reductase (NAD(P)H) -
Overview
MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. -
Synonyms
MTHFR;methylenetetrahydrofolate reductase (NAD(P)H);5,10 methylenetetrahydrofolate reductase (NADPH);methylenetetrahydrofolate reductase;5,10-methylenetetrahydrofolate reductase (NADPH)
Recombinant Proteins
- Zebrafish
- Cynomolgus
- Human
- Mouse
- Mammalian Cells
- HEK293
- Yeast
- E.coli
- His
- Non
- Flag
- Avi
- Fc
- T7
- DDK
- Myc
- SUMO
Involved Pathway
MTHFR involved in several pathways and played different roles in them. We selected most pathways MTHFR participated on our site, such as One carbon pool by folate,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | IMPDH1B,IDO1,HGSNAT,AUH,CYP26C1,NT5C2,NOS3,ACSL1,STT3B,NDUFA9A |
| Carbon metabolism | ACAT2,MDH1,PDHA1B,ENO1B,OGDH,PRPS2,TPI1,SUCLG1,PC,SDHDA |
| One carbon pool by folate | MTHFD2,DHFRL1,ST20-MTHFS,AMT,MTHFS,SHMT1,MTHFD1B,ATIC,SHMT2,MTFMT |
Protein Function
MTHFR has several biochemical functions, for example, NADP binding,flavin adenine dinucleotide binding,methylenetetrahydrofolate reductase (NAD(P)H) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFR itself. We selected most functions MTHFR had, and list some proteins which have the same functions with MTHFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | UGT1A6A,HSPD1,FBN1,GIT1,CALY,CDKN1A,WASF1,CDK2,PDX1,RIPK3 |
| modified amino acid binding | CBS,CPS1,DPEP1,MUT,NOX4 |
| flavin adenine dinucleotide binding | MTRR,GCDHB,TXNRD3,ETFA,DLD,MAOB,MTO1,AIFM2,ACOX1,ACADSB |
| NADP binding | NOS1,GAPDH,CRYZL1,SPR,FMO1,ASPDH,IDH1,POR,FMO2,DHFRL1 |
Interacting Protein
MTHFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFR.
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References
- van Dijkhuizen, EHP; Calasan, MB; et al. Prediction of Methotrexate Intolerance in Juvenile Idiopathic Arthritis: a prospective, observational cohort study. PEDIATRIC RHEUMATOLOGY 13:-(2015).
- Qi, XS; Wu, FF; et al. Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis: an observational study with a systematic review of the literature. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 27:77-83(2015).
