MTHFD2
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Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -
Overview
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. -
Synonyms
MTHFD2;methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase;bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial;NAD-dependent methylene tetrahydrofolate dehydrogenase cycloh
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- T7
- DDK
- Myc
- GST
- Non
- SUMO
- Flag
- Avi
- Fc
Involved Pathway
MTHFD2 involved in several pathways and played different roles in them. We selected most pathways MTHFD2 participated on our site, such as Metabolic pathways,Nucleotide Metabolism,One Carbon Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| folate transformations I | ALDH1L1,MTHFSD,ALDH1L2 |
| One Carbon Metabolism | ST20-MTHFS,MTHFS,MTFMT,AHCY,ALDH1L1,FTCD |
| Trans-sulfuration and one carbon metabolism | DNMT3L |
| One carbon pool by folate | MTHFD2L,DHFRL1,MTHFD1B,ALDH1L2,MTR,AMT,TYMS,GART,MTFMT,MTHFS |
| Nucleotide Metabolism | ADSL,OAZ1,ADSS |
| Metabolic pathways | EHHADH,ENO1B,DHRS9,AOX3L1,GRHPR,RDH8B,TPI1A,CSAD,DAO.2,POLR2J |
Protein Function
MTHFD2 has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity,magnesium ion binding,methenyltetrahydrofolate cyclohydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2 itself. We selected most functions MTHFD2 had, and list some proteins which have the same functions with MTHFD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | MTHFD1,MTHFD2L |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | MTHFD2L,MTHFD1,MTHFD1B |
| methenyltetrahydrofolate cyclohydrolase activity | MTHFD1B,MTHFD2L,MTHFD1 |
| NOT formate-tetrahydrofolate ligase activity | MTHFD2L |
| phosphate ion binding | GNG12,PNP,G6PC,SH2B3,SLC34A2,RELA,ADSSL1,OTC,RPH3A,ADSS |
| magnesium ion binding | PTEN,MAPK12,DCTPP1,IMPA1,NT5C1BA,GTPBP5,NUDT16,ADPRH,CIB2,PGM3 |
Interacting Protein
MTHFD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD2.
MCC;PSMD13;PARP3;NAGK;Nek2;nef;Lmna;LRRK2;P
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