MRPL40

  • Official Full Name

    mitochondrial ribosomal protein L40

  • Overview

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.

  • Synonyms

    MRPL40;mitochondrial ribosomal protein L40;NLVCF, nuclear localization signal deleted in velocardiofacial syndrome;39S ribosomal protein L40, mitochondrial;MRP L22;mitochondrial;39S ribosomal protein L40;39S ribosomal protein L40, mitochondrial precursor;FLJ41774;L40mt;MGC9400;MRP 40;MRP-L40;MRP40;MRPL22;NLVCF;Nuclear localization signal containing protein deleted in velocardiofacial syndrome;Nuclear localization signal-containing protein deleted in velocardiofacial syndrome;RM40_HUMAN;Up-regulated in metastasis;URIM;nuclear localization signal deleted in velocardiofacial syndrome;MRP-L22

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MRPL40-1003H Recombinant Human MRPL40, GST-tagged E.coli Human GST 1-206aa
MRPL40-1331Z Recombinant Zebrafish MRPL40 Mammalian Cells Zebrafish His
MRPL40-146H Recombinant Human MRPL40, His-tagged HEK293 Human His 47-206 a.a.
MRPL40-2845R Recombinant Rhesus monkey MRPL40 Protein, His-tagged Mammalian Cells Rhesus macaque His
MRPL40-3773R Recombinant Rat MRPL40 Protein Mammalian Cells Rat His
MRPL40-4169HCL Recombinant Human MRPL40 293 Cell Lysate HEK293 Human Non
MRPL40-2665R Recombinant Rhesus Macaque MRPL40 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MRPL40-2665R-B Recombinant Rhesus Macaque MRPL40 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MRPL40-3432R Recombinant Rat MRPL40 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
MRPL40-3432R-B Recombinant Rat MRPL40 Protein Pre-coupled Magnetic Beads HEK293 Rat
MRPL40-5584H Recombinant Human MRPL40 Protein, GST-tagged Wheat Germ Human GST
MRPL40-6419HF Recombinant Full Length Human MRPL40 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 206 amino acids

    Involved Pathway

    MRPL40 involved in several pathways and played different roles in them. We selected most pathways MRPL40 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial translation termination ICT1,MRPS33,MRPL10,MRPL44,DAP3,MRRF,MRPS24,MRPL50,MRPS23,MRPS28
    Organelle biogenesis and maintenance C10orf2,DAP3,MRPL52,ATAT1,B9D1,LZTFL1,WDR19,GADD45GIP1,IFT74,MRPS22
    Mitochondrial translation initiation ICT1,MRPL54,MRPL44,MRPL48,CHCHD1,MRPL49,MRPL3,MRPL51,MRPS26,MRPL55
    Mitochondrial translation elongation MRPL53,MRPL46,MRPL39,MRPL3,MRPL48,MRPL50,MRPL42,AURKAIP1,MRPS25,MRPS28
    Mitochondrial translation MRPS33,MRPS31,MRPS34,MRPL55,MRPS30,MRPL52,DAP3,CHCHD1,MTIF3,MRPL51

    Protein Function

    MRPL40 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL40 itself. We selected most functions MRPL40 had, and list some proteins which have the same functions with MRPL40. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding PRDX1,PRPF40A,CFAP20,RTF1,NOL11,HELZ2,RPL12,SAMSN1,RPS18,PRPF4B
    protein binding PPP4R2,DIABLO,NF1,TNFRSF1A,RHOBTB3,RPS3,CNIH4,NIPBL,TAL1,NUDT10

    Interacting Protein

    MRPL40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL40 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL40.

    TRIM27;TFCP2;KRT31;NOTCH2NL;HLA-B;USP44;HSPB1;ssrna_ug

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