MPL
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Official Full Name
myeloproliferative leukemia virus oncogene -
Overview
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. -
Synonyms
myeloproliferative leukemia virus oncogene;CD110;TPO-R;c-mpl;hlb219;c-mpl-I;c-mpl-II;MPLV;TPOR;THCYT2
Recombinant Proteins
- Mouse
- Cynomolgus
- Zebrafish
- Chicken
- Rat
- Human
- Mammalian cells
- C-His
- Mammalian Cell
- Insect Cell
- E.coli
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- Fc
- His
- His&T7
- Non
- His&Fc&Avi
- GST
Involved Pathway
MPL involved in several pathways and played different roles in them. We selected most pathways MPL participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | PRL,Ifnl2,IFNG,PIK3R2,CRLF2,IL23,CRFB4,MTOR,PRLR,GM2002 |
| Cytokine-cytokine receptor interaction | IFNA10,PF4V1,IFNB,CCL23,HGF,Il4ra,KDR,LTB,BMPR1AB,CSF3 |
Protein Function
MPL has several biochemical functions, for example, protein binding,thrombopoietin receptor activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MPL itself. We selected most functions MPL had, and list some proteins which have the same functions with MPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GLI1,C4orf33,KCNH2,PCBD2,TSR2,PPIA,ADAM10,SOCS1,NOP2,WIBG |
| transmembrane signaling receptor activity | CR2,ERBB3,CD69,TLR5,TLR2-2,IL27RA,TNFRSF10C,LAG3,CLEC2D,TLR1 |
Interacting Protein
MPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MPL.
JAK2;ATXN2L
Resources
Research Area
Other Cytokines & ReceptorsNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Megakaryocytes
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References
- Bernstein, DI; Atmar, RL; et al. Norovirus Vaccine Against Experimental Human GII.4 Virus Illness: A Challenge Study in Healthy Adults. JOURNAL OF INFECTIOUS DISEASES 211:870-878(2015).
- Leroux-Roels, G; Van Belle, P; et al. Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination. VACCINE 33:1084-1091(2015).
