MPI
-
Official Full Name
mannose phosphate isomerase -
Overview
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions.Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. -
Synonyms
MPI;mannose phosphate isomerase;mannose-6-phosphate isomerase;mannose 6 phosphate isomerase;PMI1;Phosphohexomutase;Phosphomannose isomerase;FLJ39201;MGC94106;MPI_HUMAN;PMI;phosphomannose isomerase 1;mannose-6- phosphate isomerase;CDG1B
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Cynomolgus
- Mouse
- Human
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
MPI involved in several pathways and played different roles in them. We selected most pathways MPI participated on our site, such as Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fructose and mannose metabolism | ALDOC,DHRS13L1,AKR1B10,GMPPAB,AKR1B1L,HK2,FBP2,ALDOCB,PFKMA,GMDS |
| Amino sugar and nucleotide sugar metabolism | GFPT2,PGM1,HK1,HEXA,FPGT,GPI1,GMPPB,CHIA.4,PGM3,GPR19 |
| Metabolic pathways | SDHC,MAPK1IP1L,Akr1b3,IDI1,CYP2C50,IDUA,PANK1,PMM1,EXT1A,UPRT |
Protein Function
MPI has several biochemical functions, for example, mannose-6-phosphate isomerase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPI itself. We selected most functions MPI had, and list some proteins which have the same functions with MPI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF14,KMT2A,TMEM163,SRSF7B,MGRN1A,GTF2H2,KAT6B,ZDHHC17,CIZ1,POLR2L |
Interacting Protein
MPI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPI here. Most of them are supplied by our site. Hope this information will be useful for your research of MPI.
Resources
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References
- Yoshimura, K; Harada, S; et al. Impact of maraviroc-resistant and low-CCR5-adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies. JOURNAL OF GENERAL VIROLOGY 95:1816-1826(2014).
- Shmuely, H; Wattad, M; et al. Association of Helicobacter pylori with Coronary Artery Disease and Myocardial Infarction Assessed by Myocardial Perfusion Imaging. ISRAEL MEDICAL ASSOCIATION JOURNAL 16:341-346(2014).
