MOGAT1
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Official Full Name
monoacylglycerol O-acyltransferase 1 -
Overview
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the;precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 (PubMed;12077311)). -
Synonyms
MOGAT1;monoacylglycerol O-acyltransferase 1;DGAT2L1, diacylglycerol O acyltransferase 2 like 1;2-acylglycerol O-acyltransferase 1;DGAT2L;MGAT1;1110064N14Rik;Diacylglycerol O acyltransferase 2 like 1;MGC118035;0610030A14Rik;Acyl CoA:monoacylglycerol acyltransferase 1;DGAT2L1;Diacylglycerol acyltransferase 2 like;Diacylglycerol O-acyltransferase candidate 2;hDC2;mDC2;Monoacylglycerol O acyltransferase 1;OTTMUSP00000025181;diacylglycerol O-acyltransferase 2 like 1;acyl-CoA:monoacylglycerol acyltransferase 1;diacylglycerol acyltransferase 2-like protein 1
Recombinant Proteins
- Mouse
- Human
- Mus musculus
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Bovine
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
MOGAT1 involved in several pathways and played different roles in them. We selected most pathways MOGAT1 participated on our site, such as Glycerolipid metabolism,Triacylglyceride Synthesis,triacylglycerol biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOGAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | DGAT1A,MOGAT3A,DGKAA,LPIN3,PPAP2D,ALDH9A1B,DGAT1,CEL.1,MOGAT3,GK2 |
| triacylglycerol biosynthesis | LPPR2,LPPR3,PPAPDC1A |
Protein Function
MOGAT1 has several biochemical functions, for example, 2-acylglycerol O-acyltransferase activity,diacylglycerol O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MOGAT1 itself. We selected most functions MOGAT1 had, and list some proteins which have the same functions with MOGAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2-acylglycerol O-acyltransferase activity | DGAT1,MOGAT3,DGAT2 |
| diacylglycerol O-acyltransferase activity | MOGAT3,DGAT1,DGAT2,DGAT1B,DGAT1A |
Interacting Protein
MOGAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOGAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MOGAT1.
Resources
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References
- McIntosh, AL; Huang, H; et al. Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-alpha activation in cultured human female hepatocytes. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 307:G164-G176(2014).
- Jeon, S; Park, YJ; et al. Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE-/- mice fed a high- fat diet. MOLECULAR NUTRITION & FOOD RESEARCH 58:830-841(2014).
