MMP19
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Official Full Name
matrix metallopeptidase 19 -
Overview
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] -
Synonyms
MMP19;matrix metallopeptidase 19;MMP18;RASI-1;matrix metalloproteinase-19;matrix metalloproteinase-18;matrix metalloproteinase RASI;matrix metalloproteinase-beta19
Recombinant Proteins
- Human
- Mouse
- Hamster
- E.coli
- HEK293
- CHO
- Mamanlian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&T7
- Flag
- GST
Involved Pathway
MMP19 involved in several pathways and played different roles in them. We selected most pathways MMP19 participated on our site, such as Collagen degradation,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | BMP1A,BMP1B,CTSD,TLL1,ADAM8A,CTSLL,MMP20,COL9A1,NID1,ELANE |
| Collagen degradation | MGC174155,CTSK,MMP15,CTSD,ELANE,MMP8,CTSLL,CTSL1,MMP20,CTSB |
| Extracellular matrix organization | ADAM9,CTS7,NID1,ICAM4,ADAMTS2,MMP10,LOXL1,FMOD,MMP8,MFAP2 |
| Matrix Metalloproteinases | MMP17,MMP26,MMP11,MMP10,MMP27,TIMP4,BSG,MMP24,MMP12,TIMP2 |
Protein Function
MMP19 has several biochemical functions, for example, calcium ion binding,metalloendopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP19 itself. We selected most functions MMP19 had, and list some proteins which have the same functions with MMP19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SRI,PLCB1,SGCA,JAG1,CRACR2B,DGKA,MBL1,KCNIP1B,F9B,CLSTN1 |
| metalloendopeptidase activity | FAP,MMP9,ADAMTS20,ADAM10,ADAM12,C6AST1,ADAM10B,MMP24,AFG3L2,MMP16 |
| zinc ion binding | ZCCHC11,PRKCBP1L,RNF31,S100A8,GCM1,TRIM43B,USP39,ZNRD1,BMP1A,ZFAND1 |
Interacting Protein
MMP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP19.
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