MGP
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Official Full Name
Matrix Gla Protein -
Overview
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
matrix Gla protein;Cell growth-inhibiting gene 36 protein;MGLAP;NTI;OTTHUMP00000239335;MGP;GIG36;OTTHUMP00000239337
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Cattle
- Pig
- Rabbit
- E.coli
- Mammalian Cells
- Human
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- His&GST
- His&S
- Non
- His&Fc&Avi
- His&Myc
- GST
Involved Pathway
MGP involved in several pathways and played different roles in them. We selected most pathways MGP participated on our site, such as Endochondral Ossification,Validated transcriptional targets of AP1 family members Fra1 and Fra2, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endochondral Ossification | DDR2,RUNX3,PTH,IFT88,COL2A1,PTHLHA,COL10A1A,CST5,COL10A1,KIF3A |
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 | IVL,BGLAP,USF2,CXorf15 |
Protein Function
MGP has several biochemical functions, for example, calcium ion binding,extracellular matrix structural constituent,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGP itself. We selected most functions MGP had, and list some proteins which have the same functions with MGP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | IMPG1,COMP,COL3A1,MEPE,COL1A1A,CD4,LAMA4,COL1A1,COL11A1B,COL5A3B |
| structural constituent of bone | BGLAP-RS1,BGLAP2,BGLAP |
| protein binding | CPEB3,EPB41B,OSTF1,CLN3,KCNJ3,SNAPC3,CHD2,RNF182,HNRNPH2,TMSB4X |
| calcium ion binding | PCDHB15,CALML5,F7,MAN1A1,TESCB,CD97,PCDH2G12,CAPN2A,OTOFA,CABP1B |
Interacting Protein
MGP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGP here. Most of them are supplied by our site. Hope this information will be useful for your research of MGP.
p27958-pro_0000037576
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References
- Viegas, CSB; Rafael, MS; et al. Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:399-408(2015).
- Xiao, LP; Esliger, A; et al. Nuclear Fibroblast Growth Factor 2 (FGF2) Isoforms Inhibit Bone Marrow Stromal Cell Mineralization Through FGF23/FGFR/MAPK In Vitro. JOURNAL OF BONE AND MINERAL RESEARCH 28:35-45(2013).
