MGLL
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Official Full Name
Mgll monoglyceride lipase -
Overview
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of;monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several;physiological processes including pain and nociperception through hydrolysis of the endocannabinoid;2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
MGLL;monoglyceride lipase;monoacylglycerol lipase;Mgl;Magl;AA589436
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- Yeast
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- GST
- Flag
Involved Pathway
MGLL involved in several pathways and played different roles in them. We selected most pathways MGLL participated on our site, such as Acyl chain remodeling of DAG and TAG,Arachidonate production from DAG,Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGLL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Effects of PIP2 hydrolysis | PRKCHB,TRPC3,TAE1,RASGRP2,DGKA,TRPC7,DGKB,ABHD12,DGKQ,ABHD6B |
| GPCR downstream signaling | APLN,ADRB3,TAS2R3,GPR18,OPN5,TRPC3,VIP,TAC3,OR52J3,ARHGEF25 |
| Glycerolipid metabolism | LIPC,AKR1B8,LPL,DGKQ,MBOAT2,LIPG,DGKZ,PPAP2CB,CELL,LCLAT1 |
| Arachidonate production from DAG | ABHD6B,ABHD12 |
| Glycerophospholipid biosynthesis | GPAT2,DGAT1B,CPNE7,CPNE6,CPNE3,PLD4,CHKB,BCHE,CEPT1,PLB1 |
| Acyl chain remodeling of DAG and TAG | DGAT1B,AWAT1,AWAT2 |
| Gastrin-CREB signalling pathway via PKC and MAPK | GCGB,EDN1,NPFFR2,NPSR1,UTS2,OPN4B,GPR4,OPN4A,PMCH,CCK |
| G alpha (q) signalling events | TAC3,APPA,GPR4,NMU,GPR68,GPR65,TRPC7,PROKR1A,OXTRL,MLN |
Protein Function
MGLL has several biochemical functions, for example, acylglycerol lipase activity,lysophospholipase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGLL itself. We selected most functions MGLL had, and list some proteins which have the same functions with MGLL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acylglycerol lipase activity | ABHD6,ABHD12,FAAH,PNLIPRP2 |
| protein homodimerization activity | SEPHS1,ZFP652,ACVR1,WHRN,GCA,HSP90AA1,DMRTC1B,ERBB3,CCDC88A,GDNF |
| lysophospholipase activity | PNPLA7,PNPLA6,PNPLA7A,ENPP2,PNPLA8,LYPLA1,PLA2G4B,ASPG,LYPLAL1,Cel |
Interacting Protein
MGLL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGLL here. Most of them are supplied by our site. Hope this information will be useful for your research of MGLL.
CHGB;mdtI;q5ngv3_fratt
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References
- Njie, YF; He, F; et al. Aqueous humor outflow effects of 2-arachidonylglycerol. EXPERIMENTAL EYE RESEARCH 87:106-114(2008).
- Hamosh, M; et al. Protective function of proteins and lipids in human milk. BIOLOGY OF THE NEONATE 74:163-176(1998).
- Cotes, K; Dhouib, R; et al. Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids. BIOCHEMICAL JOURNAL 408:417-427(2007).
