METAP2
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Official Full Name
methionyl aminopeptidase 2 -
Overview
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. -
Synonyms
METAP2;methionyl aminopeptidase 2;methionine aminopeptidase 2;MAP2;MNPEP;p67;Peptidase M;MAP 2;metAP 2;peptidase M 2;eIF-2-associated p67 homolog;initiation factor 2-associated 67 kDa glycoprotein;p67eIF2
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Rat
- Mouse
- S.frugiperda
- Mammalian Cells
- Insect Cells
- E.coli
- Yeast
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- HA
- Non
- His&SUMO
- Avi&Fc&His
- His&Myc
- GST
Involved Pathway
METAP2 involved in several pathways and played different roles in them. We selected most pathways METAP2 participated on our site, such as Inactivation, recovery and regulation of the phototransduction cascade,Signal Transduction,The phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with METAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Visual phototransduction | RBP3,NMT1A,RDH10,METAP2B,RBP2A,APOM,GUCA1E,MYO7AA,PPEF1,MYO7A |
| The phototransduction cascade | RLN1,METAP2A,METAP2B,GRK7,SAGB,GUCA1E,METAP1,RGS9BP,CNGA1,PPEF1 |
| Inactivation, recovery and regulation of the phototransduction cascade | NMT2,GNB5A,RLN1,NMT1,METAP1,RHOL,SAGB,METAP2A,METAP2B,NMT1A |
| Signal Transduction | CDH5,PYGO1,ARHGEF18A,NMT1B,TAS2R16,PTH2,NRP2,JUPA,EMR1,RLN1 |
Protein Function
METAP2 has several biochemical functions, for example, aminopeptidase activity,hydrolase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by METAP2 itself. We selected most functions METAP2 had, and list some proteins which have the same functions with METAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloexopeptidase activity | LAP3,DPEP2,NPEPL1,RNPEP,METAP1,DPEP1,METAP2B,METAP2A,NUDT16,DPEP3 |
| hydrolase activity | PPP4CA,PPP3CCA,PLCD3A,DHX34,PLA2G2F,GPN2,C1RA,PL10,AGBL1,CTSSB.1 |
| peptidase activity | IWS1,C6AST4,BACE1,TMPRSS7,PSMA6B,CAPN2A,MMP14B,PROCA,F9A,CPD |
| poly(A) RNA binding | PRAC,SEC61B,SCAF4,RBM19,RBM28,RPS4Y1,AGO3,MSI2,PATL1,EDF1 |
| metal ion binding | AEBP2,GTF3AB,ZNF524,TRIM55B,HPDL,DYTN,Itga10&Itgb1,NT5C2A,SNAI1,CYP26C1 |
| aminopeptidase activity | XPNPEP3,NPEPPS,ENPEP,NPEPL1,DNPEP,LTA4H,DPP9,LNPEP,METAP1,BLMH |
| protein binding | TIMM23,NOS1AP,USP10,RNF168,HNRNPH1,CRY1A,EFCAB4A,STK4,CTDSP2,CLIC1 |
Interacting Protein
METAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of METAP2.
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