MEP1B
-
Official Full Name
meprin A, beta -
Overview
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] -
Synonyms
MEP1B;meprin A, beta;meprin A subunit beta;PPH beta;meprin B;endopeptidase-2;PABA peptide hydrolase;N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta;N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- Insect Cells
- His
- Avi&Fc&His
Involved Pathway
MEP1B involved in several pathways and played different roles in them. We selected most pathways MEP1B participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | SLC16A10,SLC15A1,ACE2,SLC7A7,SLC1A5,ATP1B4,PRSS1,COL4A1,COL15A1,COL27A1 |
Protein Function
MEP1B has several biochemical functions, for example, metalloendopeptidase activity,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEP1B itself. We selected most functions MEP1B had, and list some proteins which have the same functions with MEP1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM55B,DHX58,NR1H4,ZDHHC2,MMP14,HLTF,RNF141,MT1B,KCMF1,TRIM45 |
| metalloendopeptidase activity | ADAM33,ECE1,ADAMTS1,ADAM25,HE1A,MMP19,MMP13A,ADAMTS12,MMP2,NPSN |
| protein binding | GOLPH3,EGLN1,TBC1D9B,IL6ST,TPRGL,C8orf48,CKM,TTC1,ENTPD3,WDR25 |
Interacting Protein
MEP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of MEP1B.
MMP9;npm_alk
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