MEP1A
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Official Full Name
meprin A, alpha (PABA peptide hydrolase) -
Overview
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. -
Synonyms
MEP1A;meprin A, alpha (PABA peptide hydrolase);PPHA;meprin A subunit alpha;PPH alpha;endopeptidase-2;PABA peptide hydrolase;bA268F1.1 (meprin A alpha (PABA peptide hydrolase));N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Mus musculus
- HEK293
- Mammalian Cells
- Sf21 Cells
- Insect Cells
- E.coli
- Human Cells
- His
- Non
- Avi&Fc&His
Involved Pathway
MEP1A involved in several pathways and played different roles in them. We selected most pathways MEP1A participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | KCNK5,COL13A1,COL24A1,ATP1B4,CTRL,SLC1A5,PRSS3,SLC15A1,COL6A5,COL6A4 |
Protein Function
MEP1A has several biochemical functions, for example, metalloendopeptidase activity,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEP1A itself. We selected most functions MEP1A had, and list some proteins which have the same functions with MEP1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | KMT2A,RNF175,AGBL2,GATA2A,DPF2L,RNF11A,ADAMTS13,WHSC1L1,FTR67,TRIM101 |
| metalloendopeptidase activity | ADAMTS9,ADAMTS7,ADAM8A,MMP12,PAPLN,MMP30,UQCRC2A,KEL,MME,YBEY |
| protein binding | PIH1D3,CLCF1,ARHGAP1,MARK3,C1QL1,NOTCH3,EIF4EBP3,PVRL3,NFYB,MAGED1 |
Interacting Protein
MEP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of MEP1A.
MMP9
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