MELK

  • Official Full Name

    maternal embryonic leucine zipper kinase

  • Overview

    MELK (Maternal Embryonic Leucine zipper Kinase, MPK38, KIAA0175) is a member of the Snf1/AMPK related kinase family. It is implicated in stem cell renewal, cell cycle progression and pre-m-RNA splicing . MELK is also a marker for self-renewing multipotent

  • Synonyms

    MELK;maternal embryonic leucine zipper kinase;KIAA0175;pEg3 kinase;protein kinase Eg3;protein kinase PK38;tyrosine-protein kinase MELK;HPK38

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Mouse
  • Sf9 Insect Cell
  • Mammalian Cell
  • HEK293
  • E.coli
  • Wheat Germ
  • GST
  • His
  • Non
  • His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MELK-1430H Active Recombinant Human MELK, GST-tagged Sf9 Insect Cell Human GST 1-340 aa
MELK-1059H Recombinant Human Maternal Embryonic Leucine Zipper Kinase, GST-tagged Sf9 Insect Cell Human GST 1-340 a.a.
MELK-11780Z Recombinant Zebrafish MELK Mammalian Cell Zebrafish His
MELK-30097TH Recombinant Human MELK Sf9 Insect Cell Human Non 340 amino acids
MELK-3154C Recombinant Chicken MELK Mammalian Cell Chicken His
MELK-730H Recombinant Human Maternal Embryonic Leucine Zipper Kinase Sf9 Insect Cell Human Non 1-342 a.a.
MELK-9725M Recombinant Mouse MELK Protein Mammalian Cell Mouse His
MELK-4368HCL Recombinant Human MELK 293 Cell Lysate HEK293 Human Non
MELK-1134H Recombinant Human MELK Protein (D3-V330), Tag Free E.coli Human Non D3-V330
MELK-1135H Recombinant Human MELK Protein (D3-V330), His tagged E.coli Human His D3-V330
MELK-4388H Recombinant Human MELK protein, His&Myc-tagged E.coli Human His&Myc 1-340aa
MELK-4447H Recombinant Human MELK Protein, GST-tagged Wheat Germ Human GST
MELK-4448H Active Recombinant Human MELK Protein, GST-tagged E.coli Human GST 1-493 a.a.
MELK-5473M Recombinant Mouse MELK Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MELK-5473M-B Recombinant Mouse MELK Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MELK involved in several pathways and played different roles in them. We selected most pathways MELK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MELK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    MELK has several biochemical functions, for example, ATP binding,calcium ion binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MELK itself. We selected most functions MELK had, and list some proteins which have the same functions with MELK. You can find most of the proteins on our site.

    Function Related Protein
    non-membrane spanning protein tyrosine kinase activity WEE2,FES,PKDCC,LYN,YES1,HCK,EIF2AK2,PTK6,Fert2,PTK2
    protein binding CAMK1,ARL6IP5,RAB17,DNAJC10,NME1,SGSM3,TUBA1A,PIAS4,PID1,TRIM28
    ATP binding ADCK3,HSPA1B,DNAJA1,ULK3,RPS6KA4,UBE2L3B,MAPKAPK2B,CDK4,TEP1,ERCC6L2
    lipid binding PLUNC,HSP12,BAIAP2L2B,CPTP,O3far1,BPIFB2,COQ9,PITPNC1,APOL1,PFN3
    calcium ion binding CDH1,CDH18,MYL7,CCDC47,MMP15,MMP10,RASGRP1,SLC25A24,RPH3AL,RCVRN
    protein serine/threonine kinase activity RPS6KC1,PAK2B,PRKDC,STRC,ROCK2A,TAF1,MTOR,BMPR1A,TAF1L,MAST2

    Interacting Protein

    MELK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MELK here. Most of them are supplied by our site. Hope this information will be useful for your research of MELK.

    BCL2L14;STK16;BABAM1;bosutinib;imatinib;purvalanol b;midostaurin;CDC5L

    Resources

    Research Area

    Apoptosis Intracellular Kinases

    References

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    Q&As

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