MELK
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Official Full Name
maternal embryonic leucine zipper kinase -
Overview
MELK (Maternal Embryonic Leucine zipper Kinase, MPK38, KIAA0175) is a member of the Snf1/AMPK related kinase family. It is implicated in stem cell renewal, cell cycle progression and pre-m-RNA splicing . MELK is also a marker for self-renewing multipotent -
Synonyms
MELK;maternal embryonic leucine zipper kinase;KIAA0175;pEg3 kinase;protein kinase Eg3;protein kinase PK38;tyrosine-protein kinase MELK;HPK38
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- GST
- His
- Non
- Myc
- Avi
- Fc
Involved Pathway
MELK involved in several pathways and played different roles in them. We selected most pathways MELK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MELK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MELK has several biochemical functions, for example, ATP binding,calcium ion binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MELK itself. We selected most functions MELK had, and list some proteins which have the same functions with MELK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| non-membrane spanning protein tyrosine kinase activity | YRK,ZNF143B,CSK,DYRK1A,PTK2BB,YES1,TNK2,FYNB,PTK2AA,BTK |
| protein binding | ETS1,CTCF,Trl,LMNA,PRC1,MTMR4,LOC149950,TTC30B,GATAD2A,TERF2 |
| calcium ion binding | PLCB2,LDLRB,CRNN,FKBP14,EPS15,EHD2B,ACTN3,CAPN1A,PCDH15,PCDHB14 |
| lipid binding | ACBD4,PITPNM3,BAX,SNX10A,ACBD5,MAL,PITPNM2,GLTP,Ar,FABP1A |
| protein serine/threonine kinase activity | PBK,MAP3K13,PLK3,AURKB,DCKL1B,PRKDC,CAMK2A,SPEG,CSNK1A1,KALRN |
| ATP binding | PEX6,MYHZ1.2,CDK9,NEK1,THG1L,NRBP2,P2RX6,ATAD1,MET,RIOK1 |
Interacting Protein
MELK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MELK here. Most of them are supplied by our site. Hope this information will be useful for your research of MELK.
BCL2L14;STK16;BABAM1;bosutinib;imatinib;purvalanol b;midostaurin;CDC5L
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