MED10
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Official Full Name
Mediator complex subunit 10 -
Overview
MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II. -
Synonyms
MED10;mediator complex subunit 10;L6;NUT2;TRG20;mediator of RNA polymerase II transcription subunit 10;TRG-17;TRG-20;transformation-related gene 17 protein;HNUT2;MGC5309;transformation-related gene 20 protein;mediator of RNA polymerase II transcription, subunit 10;mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae);OTTHUMP00000220564
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
MED10 involved in several pathways and played different roles in them. We selected most pathways MED10 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZKSCAN1,MED13A,ZNF331,JUNB,LRPPRC,ZNF625,ZNF317,PRDM7,ZNF18,ZNF213 |
| PPARA activates gene expression | MED16,ANKRD1,PLIN2,MED31,MTF1,MED20,GRHL1,G0S2,MED19,MED22 |
| Fatty acid, triacylglycerol, and ketone body metabolism | MTF1,ACAD11,ABCA1,CPT2,MED23,MED19,SLC25A20,ACOT11B,STIL,ACOT2 |
| Metabolism | CERS4A,KCNJ11,DIO2,MMS19,PAICS,UCP2,MED16,UROC1,AHCY,PNPLA8 |
| Metabolism of lipids and lipoproteins | DPEP1,PPP1R2,FABP11B,SLC27A2A,DHCR24,LPA,ECI1,ACER1,FABP11A,ACOT11 |
| Gene Expression | ADAT3,ADAT1,MADD,SKIB,HNRNPH1L,SNAPC4,HNRNPL,DCP1B,EXOSC8,RPP14 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED29,MED19,MED18,MED16,MED22,GRHL1,MED7,MTF1,CTGF,MED9 |
| Developmental Biology | CLTC,MED26,AP2M1,MED31,DUSP2,MED25,BNIP2,ARPC2,DPYSL3,EBF1 |
Protein Function
MED10 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED10 itself. We selected most functions MED10 had, and list some proteins which have the same functions with MED10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED13L,MED8,CNOT2,MED11,MED13B,NKX2-5,PPARGC1B,MED12,MED13,TP53BP1 |
| protein binding | CX3CL1,MCEE,NSMCE1,INO80,IGF2BP1,USH2A,PKMYT1,PKD1,DYX1C1,NFKB2 |
| ubiquitin protein ligase activity | RAD18,UBE2Z,RNF144B,RFFL,RFWD2,SIAH1A,UBE2NB,RNF146,MED24,RABGEF1 |
Interacting Protein
MED10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED10.
MED19;MED8;MED17
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References
- Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
- Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).
