MDM4
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Official Full Name
MDM4, p53 regulator -
Overview
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] -
Synonyms
MDM4;MDM4, p53 regulator;HDMX;MDMX;MRP1;protein Mdm4;protein Mdmx;MDM4 protein variant G;MDM4 protein variant Y;MDM4-related protein 1;mdm2-like p53-binding protein;Mdm4 p53 binding protein homolog;double minute 4, human homolog of;p53-binding protein
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MDM4-12004Z | Recombinant Zebrafish MDM4 | Mammalian Cells | Zebrafish | His |
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| MDM4-194H | Recombinant Human MDM4, His-tagged | E.coli | Human | His | 1-137 a.a. |
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| MDM4-27382TH | Recombinant Human MDM4 | Wheat Germ | Human | Non | 110 amino acids |
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| MDM4-29757TH | Recombinant Human MDM4 | Wheat Germ | Human | Non | 490 amino acids |
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| MDM4-3631R | Recombinant Rat MDM4 Protein | Mammalian Cells | Rat | His |
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| MDM4-9668M | Recombinant Mouse MDM4 Protein | Mammalian Cells | Mouse | His |
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| MDM4-4403HCL | Recombinant Human MDM4 293 Cell Lysate | HEK293 | Human | Non |
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| MDM4-0090H | Recombinant Human MDM4 Protein (T2-A490), Tag Free | E.coli | Human | Non | T2-A490 |
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| MDM4-0091H | Recombinant Human MDM4 Protein (T2-A490), His tagged | E.coli | Human | His | T2-A490 |
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| MDM4-30181H | Recombinant Human MDM4 protein, GST-tagged | E.coli | Human | GST | Met1-Ser332 |
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| MDM4-302HF | Recombinant Full Length Human MDM4 Protein | In Vitro Cell Free System | Human | Full L. 490 amino acids |
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| MDM4-3287R | Recombinant Rat MDM4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| MDM4-3287R-B | Recombinant Rat MDM4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| MDM4-4386H | Recombinant Human MDM4 protein, His -tagged | E.coli | Human | His | 1-490aa |
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| MDM4-4493H | Recombinant Human MDM4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MDM4-5433M | Recombinant Mouse MDM4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MDM4-5433M-B | Recombinant Mouse MDM4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MDM4-6114HF | Recombinant Full Length Human MDM4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 490 amino acids |
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Involved Pathway
MDM4 involved in several pathways and played different roles in them. We selected most pathways MDM4 participated on our site, such as p signaling pathway,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | TP63,CCND2,DNMT3B,DDIT4,FZD3,PDGFA,RDX,MTOR,Casp3,KIF23 |
| p signaling pathway | TP53AIP1,EI24,SESN1,CYCS,TP53,GADD45AA,RPRMA,CDK1,GADD45AB,RPRM |
Protein Function
MDM4 has several biochemical functions, for example, enzyme binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM4 itself. We selected most functions MDM4 had, and list some proteins which have the same functions with MDM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXO2,AGO3,G3BP1,POLE4,CSNK1G1,PTPN7,CACNG1,GPRASP1,RAB4B,LSM10 |
| enzyme binding | POR,HDAC10,RPS3,LAMB1,GNB2L1,TSPAN17,PEX5,UGT1A6B,HYAL2,PPARG |
| zinc ion binding | GATA2,GATA3,PXNA,UNK,PHF3,ING5,BRF1B,DTNBA,APOBEC4,PGLYRP1 |
Interacting Protein
MDM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM4.
TP53;MDM2
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