MASP2
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Official Full Name
mannan-binding lectin serine peptidase 2 -
Overview
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. -
Synonyms
MASP2;mannan-binding lectin serine peptidase 2;mannan binding lectin serine peptidase 1 pseudogene 1 , mannan binding lectin serine protease 1 pseudogene 1 , mannan binding lectin serine protease 2 , MASP1P1;mannan-binding lectin serine protease 2;Mannan binding lectin serine peptidase 2;Mannan binding lectin serine protease 2;Mannose binding protein associated serine protease 2;MAP 19;MAP19;MASP 2;MBL associated plasma protein of 19 kD;MBL associated serine protease 2;Small MBL associated protein;sMAP;small MBL-associated protein;MBL-associated serine protease 2;MBL-associated plasma protein of 19 kD;mannan-binding lectin serine protease 1 pseudogene 1;mannose-binding protein-associated serine protease 2;mannan-binding lectin serine peptidase 1 pseudogene 1;MASP-2;MASP1P1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Insect Cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
MASP2 involved in several pathways and played different roles in them. We selected most pathways MASP2 participated on our site, such as Complement and Coagulation Cascades,Complement cascade,Creation of C4 and C2 activators, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Creation of C4 and C2 activators | CRP,IgG3,IGLC2,FCN2,IGKC,HBL3,IGKV1-5,FCN3,FCN1,C1rb |
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | FCN2,FCN1,FCN3 |
| Initial triggering of complement | HBL3,GZMM,IgG3,FCN1,FCN2,FCN3,BFB,CRP,C1rb,CFD |
| Immune System | ALCAMB,CTLA4,TRIM46,TNFRSF13C,Siglece,SH3RF1,POLR3GLA,KLRF1,ACTR1A,AP1B1 |
| Complement and coagulation cascades | MASP1,F2R,C1S,SERPINA1E,SERPIND1,GM5077,SERPINF2,F5,CD59,Hc |
| Innate Immune System | S100B,CRP,CFHL2,CR1,DEFA3,PELI2,TREX1,MB21D1,NLRP3,FAM49BA |
| Complement cascade | RCA2.1,IgG3,CFHL1,FCN3,FCN2,C1rb,CFHL4,HBL3,GZMM,CR1 |
Protein Function
MASP2 has several biochemical functions, for example, calcium ion binding,calcium-dependent protein binding,complement component C4b binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MASP2 itself. We selected most functions MASP2 had, and list some proteins which have the same functions with MASP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| complement component C4b binding | CR1 |
| calcium ion binding | PCDH2AB2,C1R,LETM1,MYLPFB,DNER,CALR3B,MACF1,CCDC167,PPEF1,GM5077 |
| serine-type endopeptidase activity | PRSS37,CELA3A,CLPP,PROCA,C1S,CTRL,KLK1B11,MCPT8,PCSK2,RHBDD3 |
| protein binding | MKI67IP,IFT122,RTN4RL2B,KIF1C,NAA11,EEF2,CALB1,PALM,HCK,NRXN1 |
| peptidase activity | ADAMTS4,PM20D1.2,ADAM25,PRSS44,HPN,SPCS1,CAPN8,CTSSA,AGA,LTA4H |
| calcium-dependent protein binding | CASQ2,S100A1,DDX5,SNAP25,ANXA1,ANXA2,SELP,FCN2,S100P,S100A6 |
Interacting Protein
MASP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MASP2.
Dlg4
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References
- Bongoni, AK; Kiermeir, D; et al. Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models. TRANSPLANTATION 96:791-799(2013).
- Degn, SE; Thiel, S; et al. MAp19, the alternative splice product of the MASP2 gene. JOURNAL OF IMMUNOLOGICAL METHODS 373:89-101(2011).
