MAPK12
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Official Full Name
mitogen-activated protein kinase 12 -
Overview
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. -
Synonyms
MAPK12;mitogen-activated protein kinase 12;SAPK3;ERK6;p38gamma;PRKM12;SAPK 3;ERK-6;MAPK 12;MAP kinase 12;MAP kinase p38 gamma;stress-activated protein kinase 3;mitogen-activated protein kinase 3;extracellular signal-regulated kinase 6;mitoge
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Insect Cells
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway,Rap signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | PPP2R2D,OAS1,PIK3R3,Ifna11,IFNA12,CLDN17,CLDN2,IFNA4,Ifna15,IFNA16 |
| FoxO signaling pathway | MAPK11,INS2,MAPK8A,SIRT1,PLK3,HOMER3,SMAD3A,TGFB3,RBL2,AGAP2 |
| Progesterone-mediated oocyte maturation | CPEB1B,GNAI2,CCNB2,PIK3R1,HSP90AA1.2,PIK3CA,ADCY1A,RPS6KA1,CDC26,PDE3B |
| Inflammatory mediator regulation of TRP channels | CYP2C70,CALM2,PRKACB,PIK3R2,PLA2G4A,ASIC3,PTGER4,MAPK9,PLCB3,PPP1CB |
| Toll-like receptor signaling pathway | TLR4,TLR3,IFNA8,FADD,Ifna15,CCL3,TLR1LB,AKT2L,MAPK12B,STAT1B |
| Sphingolipid signaling pathway | PIK3R2,PPP2R5D,S1PR2,GAB2,MAP2K1,PLCB2,PPP2R5C,PPP2R5E,PPP2R2C,PLD1 |
| RIG-I-like receptor signaling pathway | NLRX1,MAPK11,TP-1,PIN1,PL10,IRF3,IKBKE,TRIM25,IFNB,IFNA1 |
| Oocyte meiosis | CALM1A,PRKACB,PPP2R5D,PPP2R5E,CDC26,CTH1,PPP3CCB,YWHAG,CAMK2D2,PRKACBA |
| Shigellosis | WAS,ELMO3,MAPK11,RIPK2,ITGB1,PFN2,IKBKG,CTTN,U2AF1L4,RAC1 |
Protein Function
MAPK12 has several biochemical functions, for example, ATP binding,MAP kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase activity | MAPK8A,MAPK14B,MAPK12B,MAPK11,MAPK7,MAPK6,MAPK15,MAPK14,NLK2,MAPK4 |
| protein serine/threonine kinase activity | MAP4K6,HIPK2,ULK4,KALRN,STK38,MAP3K10,PIM1,TSSK3,STK32B,PIK3CG |
| magnesium ion binding | RNASEH1,PRPS1A,GEM,PKLR,SERPINB1A,NLK,IMPAD1,PCK1,PRTFDC1,MAP3K5 |
| ATP binding | PIP5K1B,MAP2K6,PIP5K1C,MARS2,PTK2BB,ASCC3,ACTR1,ACTG2,ASNA1,MOV10B.2 |
| protein binding | PPFIA1,POU2AF1,DRAXIN,CSNK1G1,ID1,UBE2IB,EZR,CST9L,C7orf42,NLRC5 |
Interacting Protein
MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.
SIAH1;saicar;PKM;PTPN4;SRPK1;DUSP1;DLG1;PKN1;TERF1;GTF2I;PDGFRL;MAPK1;PRPF4B;MAPK15
MAPK12 Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
ERK (Extracellular Signal-regulated Kinases)
p38 MAP Kinases
Intracellular Signaling Molecules in Angiogenesis
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
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References
