MAP2K2
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Official Full Name
MAP2K2 mitogen-activated protein kinase kinase 2 -
Overview
MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases. -
Synonyms
MAP2K2;mitogen-activated protein kinase kinase 2;PRKMK2;dual specificity mitogen-activated protein kinase kinase 2;MEK2;MAPK/ERK kinase 2;MAP kinase kinase 2;ERK activator kinase 2;mitogen-activated protein kinase kinase 2, p45;MKK2;MAPKK2;FLJ26075
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Insect Cells
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- MBP
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | ATP1B4,ATP1A3,SLC2A1,PLCB4,MED1,SLC9A1,NOTCH2,PRKCA,ITGB3,RHEB |
| Acute myeloid leukemia | AKT3,PIK3R5,JUP,FLT3,RUNX1,BAD,RAF1,ZBTB16,MAPK3,BRAF |
| Vascular smooth muscle contraction | ROCK2B,PLA2G2F,ROCK2A,GNA12,RHOA,MYLK4,PPP1CC,CALM3,GUCY1A3,ARAF |
| Prostate Cancer | BCL2,TCF7,NKX3-1,Pdgfa&Pdgfb,SMARCA4,INS2,MAP4K1,INS1,INSRR,CCND1 |
| Glioma | PIK3R2,PDGFRA,SOS1,PIK3CD,PIK3CB,PIK3R1,PIK3R5,PRKCA,PLCG1,NRAS |
| Melanogenesis | FZD3B,CREB1A,HRASB,TYRP1B,CAMK2D,CREB3L3A,FZD8B,GNAI2B,KITLGA,PRKACA |
| cGMP-PKG signaling pathway | AGTR1B,SLC8A2,MAP2K1,NFATC3,PIK3R5,NFATC1,PDE3A,PIK3CB,MEF2A,AGTR1A |
| Central carbon metabolism in cancer | G6PDX,FGFR1,LDHA,FLT3,SLC2A2,RET,GLS,SLC7A5,PDHA2,TRP53 |
| Non-small cell lung cancer | RB1,RARB,PIK3CA,RXRA,MAPK3,BAD,PIK3CG,FOXO3,PLCG1,RXRG |
Protein Function
MAP2K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine/tyrosine kinase activity | CLK1,CLK3,PRKAA2,TESK1,DYRK4,TNK2,RPS6KA1,PRKCG,DYRK3,CLK2 |
| protein complex scaffold | C9orf142,AKAP13,CAPN3,MAGI1B,HOMER1,SLC9A3R1,ARRB2,DISC1,AXIN1,MPP7 |
| protein serine/threonine kinase activator activity | FAM20A,CAB39,CALM2,SPRY2,PARP16,STRADA,STK3,MAP2K1,CALM1,CDK5R1 |
| scaffold protein binding | KRT15,LRP4,KRT8,NLGN4X,KRT18,ADCY6,CACNA1G,GRID2,KCNH2,CRIPT |
| MAP kinase kinase activity | LRRK2,MAP2K3,MAP3K20,MAP2K2A,MAP3K14,MAPK10,MAP2K1,MAPKAPK5,MAP2K2B,SBK3 |
| protein binding | MPLKIP,FOXC1,C12orf40,QARS,ITM2C,RBL2,SMCP,GHRHR,NANOS3,LY96 |
| protein tyrosine kinase activity | MAP3K9,SRMS,PTK7A,DYRK1A,LYN,KDR,FER,FYNB,TESK2,SYK |
| PDZ domain binding | SLC26A6,TBC1D10A,DOCK4,LPAR1,PDZK1,LRP2,CXADR,LNX2,ACCN3,LIN7B |
| metal ion binding | ZSCAN2,ZNF512,ZNF526,ITGA10,ENOPH1,SMAD4,ZFP36,PCXA,FTR43,RFNG |
Interacting Protein
MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.
ARAF;RAF1;BRAF;CCNDBP1;COPS5
Resources
Research Area
Cancer Drug TargetsApoptosis Intracellular Kinases
Intracellular Kinases in the Akt Pathway
ROS and Stress Resistance
Mitogen-Activated Protein Kinase Kinases (MEKs/MKKs)
Intracellular Signaling Molecules in Angiogenesis
C-type Lectin Receptors
RAS-MAPK Pathway
Related Services
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References
