MAOA
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Official Full Name
monoamine oxidase A -
Overview
This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. -
Synonyms
MAOA;monoamine oxidase A;amine oxidase [flavin-containing] A;Amine oxidase [flavin containing] A;AOFA_HUMAN;EC 1.4.3.4;flavin containingA;HGNC:6833;MAO A;MAO-A;Monoamine oxidase type A;RP1 201D17_B.2
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Dog
- Bovine
- E.coli
- Insect cells
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- Insect Cells
- Sf9 Cells
- GST
- His
- His&T7
- Non
- Flag
- Flag&His
Involved Pathway
MAOA involved in several pathways and played different roles in them. We selected most pathways MAOA participated on our site, such as Glycine, serine and threonine metabolism,Arginine and proline metabolism,Histidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cocaine addiction | MAOB,GRM2,GNAI1,GRIN2B,PRKACA,ATF6B,GRIN2C,NFKB1,PRKACG,GPSM1 |
| Histidine metabolism | ALDH1A3,AMDHD1,ALDH9A1B,HNMT,FTCD,HDC,ASPA,ALDH3A1,UROC1,AOC1 |
| Alcoholism | HIST1H4B,HIST1H2AF,H3F3C,CALM3,GM6026,FOSB,H2AFB1,CREB3L3,CREB3,SHC1 |
| Glycine, serine and threonine metabolism | GLYCTK,CBSB,GCAT,GRHPR,SHMT2,GCSHA,TDH,SDSL,ALAS1,GATM |
| Phenylalanine metabolism | ALDH1A3,GOT2B,HPDA,GOT2,AOC2,ALDH3B2,ALDH3B1,AOC3,KEG1,GOT1 |
| Tyrosine metabolism | GOT1,TYR,AOX4,AOC3,FAHD1,HPDA,ALDH3B2,DCT,AOX2P,GOT2B |
| Drug metabolism - cytochrome P | UGT1A1,MGST1.1,FMO6P,GSTT1B,GSTM,GSTAL,AOX2P,UGT2B15,AOX3,UGT2A3 |
| Tryptophan metabolism | AANAT,GCDH,ACAT1,IL4I1,AOX4,ALDH9A1B,HADHAB,OGDHA,ALDH9A1,TPH1A |
| Arginine and proline metabolism | ALDH2.1,GOT2,AMD1,NOS3,ALDH3A2A,P4HA1B,L3HYPDH,GOT2A,P4HA3,ARG2 |
Protein Function
MAOA has several biochemical functions, for example, flavin adenine dinucleotide binding,primary amine oxidase activity,serotonin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAOA itself. We selected most functions MAOA had, and list some proteins which have the same functions with MAOA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| primary amine oxidase activity | MAOB,ABP1,AOC2,AOC3,AOC1,VCAM1 |
| serotonin binding | HTR1F,HTR2B,HTR2C,HTR3A,HTR1B,HTR1E,HTR2A |
| flavin adenine dinucleotide binding | GCDHB,MTO1,TXNRD3,ACOX2,LDHD,AOX4,KMO,MTHFR,ETFA,ACAD11 |
Interacting Protein
MAOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAOA here. Most of them are supplied by our site. Hope this information will be useful for your research of MAOA.
clorgyline;kynuramine;NDRG1;A2M
Resources
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References
- Blakeley, PM; Capron, LE; et al. Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression. JOURNAL OF PSYCHOSOMATIC RESEARCH 75:341-345(2013).
- Vitalis, T; Alvarez, C; et al. Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives. JOURNAL OF COMPARATIVE NEUROLOGY 464:392-403(2003).
- Denney, RM; Koch, H; et al. Association between monoamine oxidase A activity in human male shin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. HUMAN GENETICS 105:542-551(1999).
