MAFA
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Official Full Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -
Overview
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008] -
Synonyms
MAFA;v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A;hMafA;RIPE3b1;transcription factor MafA;transcription factor RIPE3b1;pancreatic beta-cell-specific transcriptional activator
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- Non
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAFA-28859TH | Recombinant Human MAFA | Wheat Germ | Human | Non | 87 amino acids |
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| MAFA-5302Z | Recombinant Zebrafish MAFA | Mammalian Cells | Zebrafish | His |
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| MAFA-6582C | Recombinant Chicken MAFA | Mammalian Cells | Chicken | His |
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| MAFA-9437M | Recombinant Mouse MAFA Protein | Mammalian Cells | Mouse | His |
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| MAFA-4562HCL | Recombinant Human MAFA 293 Cell Lysate | HEK293 | Human | Non |
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| MAFA-5296M | Recombinant Mouse MAFA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MAFA-5296M-B | Recombinant Mouse MAFA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAFA involved in several pathways and played different roles in them. We selected most pathways MAFA participated on our site, such as Type II diabetes mellitus,Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | NKX6-1,HNF1B,NEUROD1,PDX1,HNF4G,PAX4,PAX6,NKX6,INS1,INS |
| Type II diabetes mellitus | PRKCE,SOCS1,PRKCD,SOCS2,PIK3CA,INSR,HK2,HKDC1,MAPK9,PIK3R3 |
Protein Function
MAFA has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAFA itself. We selected most functions MAFA had, and list some proteins which have the same functions with MAFA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | KMT2A,CERS5,SPATA24,MBD3A,CDK9,KIAA0020,GM14476,FUZ,ING2,HOXC10A |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MEOX2,NR3C1,ELF3,CARF,GMEB1,PATZ1,MITF,BATF,CEBPB,MEF2C |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOSL1,SREBF1,TFE3,CEBPA,ZNF114,MITFB,MLXIPL,TCF3,NKX2-5,POU2F2 |
| protein heterodimerization activity | ADIPOR1,HIST1H2BI,HIST1H2B8,PDSS2,MYF6,HIST1H4L,VAPB,TBX18,BOKB,POLA1 |
| transcription factor activity, sequence-specific DNA binding | ZNF711,TARDBP,POU3F1,PPARDB,STAT3,ZNF71,BSX,GCM1,ZNF12,ZNF397 |
| protein homodimerization activity | CHMP4A,DMBX1,VIL1,SYNDIG1,ROPN1B,FOXP2,NADKD1,DMRTC1C2,PVRL2,BHLHB9 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | NKX2,LEF1,TRP53,CTCF,GATA1,MSX1,CSRNP3,MYF6,HIF1A,NEUROD2 |
Interacting Protein
MAFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAFA here. Most of them are supplied by our site. Hope this information will be useful for your research of MAFA.
Resources
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References
- Herath, NI; Rocques, N; et al. GSK3-mediated MAF phosphorylation in multiple myeloma as a potential therapeutic target. BLOOD CANCER JOURNAL 4:-(2014).
- Bonnavion, R; Jaafar, R; et al. Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PLOS ONE 8:-(2013).
