LTK
-
Official Full Name
leukocyte receptor tyrosine kinase -
Overview
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LTK;leukocyte receptor tyrosine kinase;leukocyte tyrosine kinase;leukocyte tyrosine kinase receptor;TYK1;ALK;Anaplastic lymphoma kinase;LTK_HUMAN;Protein tyrosine kinase 1;TYK 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- C-His
- HEK293
- Insect Cells
- Wheat Germ
- His
- Flag&His
- Non
- GST
- Flag
- Avi&Fc&His
Involved Pathway
LTK involved in several pathways and played different roles in them. We selected most pathways LTK participated on our site, such as neural crest development, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| neural crest development | PHOX2BB,PAX7B,DLX5A,PMELA,TWIST1B,EGR2B,DLX4B,DLX3B,PMELB,SOX9B |
Protein Function
LTK has several biochemical functions, for example, ATP binding,kinase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTK itself. We selected most functions LTK had, and list some proteins which have the same functions with LTK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine kinase activity | EPHB4,FGFR1A,NTRK1,INSRB,INSRA,CSF1RA,NTRK2B,EPHA4B,TIE1,PDGFRA |
| protein kinase activity | PRKCZ,CDC7,MAP2K4A,CDK5R1,PKN2,ACVR1BA,DCLK1A,SMOK2B,RAF1B,PRKAB1 |
| kinase activity | NME2B.2,MAP4K6,FGGY,CAMK1GA,PRPS2,IGF1RA,RAF1B,MOB1BA,CAMK2B1,RPS6KAL |
| nucleotide binding | GTF2F2A,RAC1B,ZNF143B,TRIM66,FPGS,HNRNPL,SRSF12,MYH1,RAB5AA,RTCB |
| protein tyrosine kinase activity | AXL,WEE2,INSRB,SYK,HCK,NTRK2B,ALK,FGFR2,CSF1RA,MAP3K9 |
| transferase activity | TGFBR1A,PKDCCA,GGCTB,CAMK2G1,AANAT,SMYD2B,B3GNT5B,FT1,UGT5C2,METTL23 |
| ATP binding | ABCF2A,TTLL10,SMC1AL,UBE2NA,BAT1,KIF22,GATB,TTN,PIM2,PGS1 |
Interacting Protein
LTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTK here. Most of them are supplied by our site. Hope this information will be useful for your research of LTK.
Resources
Related Services
Related Products
References
- Roll, JD; Reuther, GW; et al. ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation. PLOS ONE 7:-(2012).
- Morris, SJ; Van-Ham, II; et al. Differential desensitization of dopamine D-2 receptor isoforms by protein kinase C: The importance of receptor phosphorylation and pseudosubstrate sites. EUROPEAN JOURNAL OF PHARMACOLOGY 577:44-53(2007).
