LSM1
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Official Full Name
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) -
Overview
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. -
Synonyms
LSM1;LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae);U6 snRNA-associated Sm-like protein LSm1;anti-LSM1;Cancer associated Sm like protein;Cancer associated Sm-like;Cancer-associated Sm-like;CASM;Lsm1 protein;LSM1_HUMAN;Small nuclear ribonuclear CaSm;U6 snRNA associated Sm-like protein LSm1;YJL124C;cancer-associated Sm-like protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LSM1-2818H | Recombinant Human LSM1, His-tagged | E.coli | Human | His |
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| LSM1-3006H | Recombinant Human LSM1 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae), T7-tagged | E.coli | Human | T7 |
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| LSM1-331H | Recombinant Human LSM1 protein(Met1-Tyr133), His-tagged | E.coli | Human | His | Met1-Tyr133 |
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| LSM1-985Z | Recombinant Zebrafish LSM1 | Mammalian Cells | Zebrafish | His |
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| LSM1-4613HCL | Recombinant Human LSM1 293 Cell Lysate | HEK293 | Human | Non |
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| Lsm1-3852M | Recombinant Mouse Lsm1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| LSM1-4202H | Recombinant Human LSM1 Protein (Met1-Tyr133), C-His tagged | E.coli | Human | His | Met1-Tyr133 |
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| LSM1-4618H | Recombinant Human LSM1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LSM1-6121HF | Recombinant Full Length Human LSM1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 133 amino acids |
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| LSM1-618H | Recombinant Human LSM1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
LSM1 involved in several pathways and played different roles in them. We selected most pathways LSM1 participated on our site, such as Arginine and proline metabolism,Creatine metabolism,Glycine, serine and threonine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LSM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycine, serine and threonine metabolism | DAO.3,PGAM1A,SDS,GLYCTK,ALAS2,DAO.1,GLDC,GRHPR,DMGDH,AOC3 |
| Metabolism of amino acids and derivatives | DCT,NQO1,AMD2,SLC6A8,AHCY,BCKDK,GLS2B,OAZ2B,AMDHD1,BHMT2 |
| Creatine metabolism | CKMT2,CKBA,CKMT1B,SLC6A8,SLC6A12,CKB,CKMB,CKMT2A,SLC6A7,CKM |
| Arginine and proline metabolism | LAP3,DAO.3,AGMAT,ALDH9A1A.1,DAO.2,ALDH2,CNDP1,SAT2,GOT2,CKBB |
| Metabolic pathways | TK2,GRHPR,HMGCRA,ATP6V0CA,PTGS2,PDXKA,PI4KA,PYGB,POLR3G,MBOAT2B |
| Urea cycle and metabolism of amino groups | CKM,CKB |
| Metabolism | NOSTRIN,PDK2,SCP2B,ST3GAL3A,AWAT2,ABHD10,AK7,AQP1A.2,PNPLA8,CYB5A |
| Metabolism of polyamines | CKM,CKBA,NQO1,OAZ1A,AZIN1,SLC25A15A,SLC25A2,AMD2,OAZ3,AZIN1A |
Protein Function
LSM1 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity,guanidinoacetate N-methyltransferase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LSM1 itself. We selected most functions LSM1 had, and list some proteins which have the same functions with LSM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanidinoacetate N-methyltransferase activity | GAMT |
| S-adenosylmethionine-dependent methyltransferase activity | PRMT8B,METTL7A,RRP8,TPMT.1,LCMT1,ASMT2,MEPCE,AS3MT,TPMT.2,WBSCR27 |
| protein homodimerization activity | DMRTA1,FIGF,BAXA,GSTZ1,PVRL1B,RAB11FIP4A,PLEKHB1,SUPV3L1,CHKA,SLIT2 |
Interacting Protein
LSM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LSM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LSM1.
LSM3;LSM4;CLIC1;NARS;HSP90AA1;PSMB8;PSMB5;LSM6;RRP1B;TMEM214;q81ky6_bacan;q81wx2_bacan;EXOSC8;FAM136A
Resources
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References
- Godfrey, AC; White, AE; et al. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. RNA-A PUBLICATION OF THE RNA SOCIETY 15:1661-1672(2009).
