LPCAT2
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Official Full Name
lysophosphatidylcholine acyltransferase 2 -
Overview
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. -
Synonyms
LPCAT2;lysophosphatidylcholine acyltransferase 2;acyltransferase like 1 , AYTL1;FLJ20481;Acyltransferase like 1A;DKFZp686H22112;lpafat1;1 acylglycerophosphocholine O acyltransferase;1 alkylglycerophosphocholine O acetyltransferase;1-acylglycerophosphocholine O-acyltransferase;1-alkylglycerophosphocholine O-acetyltransferase;A330042H22;Acetyl CoA:lyso PAF acetyltransferase;Acetyl-CoA:lyso-PAF acetyltransferase;Acetyl-CoA:lyso-platelet-activating factor acetyltransferase;acyl CoA:lysophosphatidylcholine acyltransferase 2;Acyl-CoA:lysophosphatidylcholine acyltransferase member 1;Acyltransferase-like 1;AYTL1;Aytl1a;LPC acyltransferase 2;LPCAT-2;Lyso PAF acetyltransferase;Lyso platelet activating factor (PAF) acetyltransferase;Lyso-PAF acetyltransferase;LysoPAFAT;LysoPAFAT/LPCAT2;LysoPC acyltransferase 2;OTTMUSP00000029641;PCAT2_HUMAN;RGD1563994;acyltransferase like 1;acyl-CoA:lysophosphatidylcholine acyltransferase 2;lyso-platelet-activating factor (PAF) acetyltransferase
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Cynomolgus
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
LPCAT2 involved in several pathways and played different roles in them. We selected most pathways LPCAT2 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPCAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ADH1C,ALDH3A2,CYCS,ATP5D,PIGF,GCSHB,ITPK1A,NDUFB5,PIGYL,FBP1B |
| Ether lipid metabolism | PPAP2C,PLA2G4F,PLA2G12B,PLA2G5,PLA2G6,PLB1,CHPT1,PPAP2B,PLD2,PLD3 |
| Glycerophospholipid metabolism | PLA2G2A,MBOAT1,PPAP2B,PLD1,CHATA,DGKQ,PTDSS2,CDS1,DGKE,PCYT1BA |
Protein Function
LPCAT2 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity,1-acylglycerophosphocholine O-acyltransferase activity,1-alkylglycerophosphocholine O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPCAT2 itself. We selected most functions LPCAT2 had, and list some proteins which have the same functions with LPCAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CD97,ACTN3A,ITPR3,EMR3,PCDH18B,KCNIP2,PVALB6,DGKAA,PCDHGA11,KCNIP4 |
| 1-acylglycerophosphocholine O-acyltransferase activity | LPCAT3,LPCAT4,LPCAT1,TAZ |
| 1-acylglycerol-3-phosphate O-acyltransferase activity | AGPAT9,AGPAT2,ABHD5,AGPAT9L,AGPAT1,AGPAT3,LCLAT1,AGPAT5,LYCAT,AGPAT4 |
| 1-alkylglycerophosphocholine O-acetyltransferase activity | LPCAT1,LPCAT4 |
Interacting Protein
LPCAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPCAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPCAT2.
CREB3;15-deoxy-delta(12,14;IQCB1
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References
- Sasabe, N; Keyamura, Y; et al. Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein. LIPIDS IN HEALTH AND DISEASE 13:-(2014).
