LHPP
-
Official Full Name
phospholysine phosphohistidine inorganic pyrophosphate phosphatase -
Overview
LHPP is a member of the HAD-like hydrolase superfamily. It is a unique enzyme that hydrolyzes not only oxygen-phosphorus bonds in inorganic pyrophosphate but also nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate in vitro. -
Synonyms
LHPP;phospholysine phosphohistidine inorganic pyrophosphate phosphatase;HDHD2B;hLHPP;FLJ44846;FLJ46044;MGC117251;MGC142189;MGC142191
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- His
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
LHPP involved in several pathways and played different roles in them. We selected most pathways LHPP participated on our site, such as Oxidative phosphorylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LHPP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | COX5B2,ATP12A,NDUFA3,ATP5G3,ATP6V0E1,NDUFS7,COX7A1,NDUFA11,SDHDB,MT-ATP6 |
Protein Function
LHPP has several biochemical functions, for example, inorganic diphosphatase activity,magnesium ion binding,phosphohistidine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LHPP itself. We selected most functions LHPP had, and list some proteins which have the same functions with LHPP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | ATP10A,RPS6KA5,IRAK4,PPA1B,ABL2,RRAGC,ITPK1A,GLUL,CIB4,CDC42BPB |
| inorganic diphosphatase activity | PRUNE,PPA1,PPA1B,PPA2,PPA1A |
| phosphohistidine phosphatase activity | PHPT1,PXYLP1,SACM1LB,SACM1L,TENC1,SGPP2,SACM1LA,PTPRQ,MINPP1,NT5DC3 |
| protein homodimerization activity | CHKA,PRTFDC1,EXT1,MTPAP,PVR,CTBP2A,PLOD1,IRAK3,RAB11FIP4,CRYBA1 |
Interacting Protein
LHPP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LHPP here. Most of them are supplied by our site. Hope this information will be useful for your research of LHPP.
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References
- Koike, E; Toda, S; et al. Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341:691-696(2006).
