LEO1
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Official Full Name
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -
Overview
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008] -
Synonyms
LEO1;Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae);RDL;RNA polymerase-associated protein LEO1;replicative senescence down-regulated leo1-like protein
Recombinant Proteins
- Zebrafish
- Rat
- Chicken
- Mouse
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
LEO1 involved in several pathways and played different roles in them. We selected most pathways LEO1 participated on our site, such as Formation of the beta-catenin:TCF transactivating complex,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the beta-catenin:TCF transactivating complex | BCL9,TLE4,H3F3B.1,H3F3D,SMARCA4,PYGO2,CDC73,TLE3,PYGO1,ASH2L |
| Signal Transduction | NCKIPSD,GRB10A,PROK2,BCO2L,INSL3,KIF7,LGR6,CSN2,JUPA,PDK3B |
| TCF dependent signaling in response to WNT | RSPO4,WIF1,TNKS,TLE3B,ZNRF3,SRY,RSPO2,SOX4A,RNF43,SOX9B |
| Signaling by Wnt | AES,RYK,ROR2,RNF146,SOX4B,DACT1,C,PRICKLE1,USP34,SOX9B |
Protein Function
LEO1 has several biochemical functions, for example, RNA polymerase II C-terminal domain phosphoserine binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEO1 itself. We selected most functions LEO1 had, and list some proteins which have the same functions with LEO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DYRK1A,KLHDC3,JAKMIP2,SOX-2,PAGE1,CLCF1,SRSF7,CALM3,TRIM23,TBC1D10A |
Interacting Protein
LEO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEO1.
PAF1
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References
- Chong, PSY; Zhou, JB; et al. LEO1 Is Regulated by PRL-3 and Mediates Its Oncogenic Properties in Acute Myelogenous Leukemia. CANCER RESEARCH 74:3043-3053(2014).
- Wang, JC; Dixon, SE; et al. Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation. PLOS PATHOGENS 10:-(2014).
