LECT2
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Official Full Name
leukocyte cell-derived chemotaxin 2 -
Overview
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. -
Synonyms
LECT2;leukocyte cell-derived chemotaxin 2;leukocyte cell-derived chemotaxin-2;chm II;chm2;Chondromodulin II;hLECT2;LECT 2;Leukocyte cell derived chemotaxin 2;MGC126628;chondromodulin-II;OTTHUMP00000159422;OTTHUMP00000223349;OTTHUMP00000228311;chm-II
Recombinant Proteins
- Rhesus macaque
- Mouse
- Rat
- Chicken
- Human
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- His
- His&T7
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
LECT2 involved in several pathways and played different roles in them. We selected most pathways LECT2 participated on our site, such as C-MYB transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with LECT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| C-MYB transcription factor network | MYF6,CREBBP,ADORA2B,TRIM28,PRTN3,COL1A2,SKI,CSF1R,ELANE,PTCRA |
Protein Function
LECT2 has several biochemical functions, for example, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LECT2 itself. We selected most functions LECT2 had, and list some proteins which have the same functions with LECT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SELK,ESYT2,SOX10,TNN,ALCAMA,L1CAM,CLDN15,SEPT7,DYNLT1,AGXT2 |
Interacting Protein
LECT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LECT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LECT2.
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References
- Paueksakon, P; Fogo, AB; et al. Leukocyte chemotactic factor 2 amyloidosis cannot be reliably diagnosed by immunohistochemical staining. HUMAN PATHOLOGY 45:1445-1450(2014).
- Murphy, CL; Wang, SC; et al. Leukocyte Chemotactic Factor 2 (LECT2)-Associated Renal Amyloidosis: A Case Series. AMERICAN JOURNAL OF KIDNEY DISEASES 56:1100-1107(2010).
