LAMA5
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Official Full Name
laminin, alpha 5 -
Overview
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. -
Synonyms
LAMA5;laminin, alpha 5;laminin subunit alpha-5;laminin alpha-5 chain;laminin-10 subunit alpha;laminin-11 subunit alpha;laminin-15 subunit alpha;KIAA1907
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Fc
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LAMA5-3613Z | Recombinant Zebrafish LAMA5 | Mammalian Cells | Zebrafish | His |
|
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| LAMA5-968HCL | Recombinant Human LAMA5 cell lysate | Human | Non |
|
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| LAMA5-0356H | Active Recombinant Human LAMA5 protein, Fc-tagged | HEK293 | Human | Fc | 2655-3327;1714-1786;1528-1609 a.a. |
|
| LAMA5-0375H | Active Recombinant Human LAMA5 protein, Fc-tagged | HEK293 | Human | Fc | 1573-1798 a.a. |
|
| LAMA5-1787H | Recombinant Human LAMA5 Protein (3401-3692 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 3401-3692 aa |
|
| Lama5-217M | Recombinant Mouse Lama5 Protein, His-tagged | E.coli | Mouse | His | Glu3517~His3718 |
|
| LAMA5-2384H | Recombinant Human LAMA5 Protein, His-tagged | E.coli | Human | His | Pro2736-Cys2929 |
|
| LAMA5-2461H | Recombinant Human LAMA5 protein(2381-2460 aa), C-His-tagged | E.coli | Human | His | 2381-2460 aa |
|
Involved Pathway
LAMA5 involved in several pathways and played different roles in them. We selected most pathways LAMA5 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | Casp3,ERBB2,MLH1,PPARG,IGF1,LPAR4,BRAF,FGF7,APC,DAPK2 |
| Toxoplasmosis | IL10RB,HLA-DMB,ALOX5,HLA-DQA2,LAMB4,PIK3CB,TLR2,NOS2,HLA-DRA,BIRC7 |
| PIK-Akt signaling pathway | FASLG,INS2,GNG7,YWHAE,COL27A1,STK11,FGFR1,GNB3,IKBKG,IFNA5 |
| Focal adhesion | ITGB5,ROCK1,LAMC2,PTK2,DIAP1,COL2A1,MAPK9,COL6A3,GRB2A,MYL7 |
| ECM-receptor interaction | Npnt,ITGA11A,HMMR,COL6A5,COL6A6,VTNB,COL6A4,THBS1,ITGA1,THBS4 |
| Small cell lung cancer | PIK3R3,ITGB1,LAMB2,TRAF3,CKS2,IKBKB,CCNE1,BIRC2,PIK3CB,COL4A1 |
| Amoebiasis | RELA,C9,ACTN3,CXCL8,RAB5B,PIK3R1,COL4A6,COL5A2,COL4A1,PRKACG |
Protein Function
LAMA5 has several biochemical functions, for example, integrin binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA5 itself. We selected most functions LAMA5 had, and list some proteins which have the same functions with LAMA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | CLDN5A,CLDN15B,FGA,CLDNC,COL18A1,LMNTD1,CLDNK,CLDN3,KRT1-C5,NEFH |
| integrin binding | THBS1,ADAM9,ADAM15,PXN,ITGA6,SRC,CIB2,P4HB,KDR,NISCH |
Interacting Protein
LAMA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA5.
DAG1;LAMC1;TFAP2A;CRKL;SMAD2;tktA;ATF7IP;yfiS;MUC7;dnaA;TFAP2C;BTBD10;q9wmx2-pro_0000037548;Mast3;Cenpe;ssrna_ug;RNASEH2A;cona_canen
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References
- Hamill, KJ; Langbein, L; et al. Identification of a Novel Family of Laminin N-terminal Alternate Splice Isoforms STRUCTURAL AND FUNCTIONAL CHARACTERIZATION. JOURNAL OF BIOLOGICAL CHEMISTRY 284:35588-35596(2009).
- Rebustini, IT; Patel, VN; et al. Laminin alpha 5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta 1 integrin signaling. DEVELOPMENTAL BIOLOGY 308:15-29(2007).
